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VBASS enables integration of single cell gene expression data in Bayesian association analysis of rare variants

Rare or de novo variants have substantial contribution to human diseases, but the statistical power to identify risk genes by rare variants is generally low due to rarity of genotype data. Previous studies have shown that risk genes usually have high expression in relevant cell types, although for m...

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Detalles Bibliográficos
Autores principales: Zhong, Guojie, Choi, Yoolim A., Shen, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368729/
https://www.ncbi.nlm.nih.gov/pubmed/37491581
http://dx.doi.org/10.1038/s42003-023-05155-9

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