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Generalizability of machine learning methods in detecting adverse drug events from clinical narratives in electronic medical records
We assessed the generalizability of machine learning methods using natural language processing (NLP) techniques to detect adverse drug events (ADEs) from clinical narratives in electronic medical records (EMRs). We constructed a new corpus correlating drugs with adverse drug events using 1,394 clini...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368879/ https://www.ncbi.nlm.nih.gov/pubmed/37502211 http://dx.doi.org/10.3389/fphar.2023.1218679 |
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author | Zitu, Md Muntasir Zhang, Shijun Owen, Dwight H. Chiang, Chienwei Li, Lang |
author_facet | Zitu, Md Muntasir Zhang, Shijun Owen, Dwight H. Chiang, Chienwei Li, Lang |
author_sort | Zitu, Md Muntasir |
collection | PubMed |
description | We assessed the generalizability of machine learning methods using natural language processing (NLP) techniques to detect adverse drug events (ADEs) from clinical narratives in electronic medical records (EMRs). We constructed a new corpus correlating drugs with adverse drug events using 1,394 clinical notes of 47 randomly selected patients who received immune checkpoint inhibitors (ICIs) from 2011 to 2018 at The Ohio State University James Cancer Hospital, annotating 189 drug-ADE relations in single sentences within the medical records. We also used data from Harvard’s publicly available 2018 National Clinical Challenge (n2c2), which includes 505 discharge summaries with annotations of 1,355 single-sentence drug-ADE relations. We applied classical machine learning (support vector machine (SVM)), deep learning (convolutional neural network (CNN) and bidirectional long short-term memory (BiLSTM)), and state-of-the-art transformer-based (bidirectional encoder representations from transformers (BERT) and ClinicalBERT) methods trained and tested in the two different corpora and compared performance among them to detect drug–ADE relationships. ClinicalBERT detected drug–ADE relationships better than the other methods when trained using our dataset and tested in n2c2 (ClinicalBERT F-score, 0.78; other methods, F-scores, 0.61–0.73) and when trained using the n2c2 dataset and tested in ours (ClinicalBERT F-score, 0.74; other methods, F-scores, 0.55–0.72). Comparison among several machine learning methods demonstrated the superior performance and, therefore, the greatest generalizability of findings of ClinicalBERT for the detection of drug–ADE relations from clinical narratives in electronic medical records. |
format | Online Article Text |
id | pubmed-10368879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103688792023-07-27 Generalizability of machine learning methods in detecting adverse drug events from clinical narratives in electronic medical records Zitu, Md Muntasir Zhang, Shijun Owen, Dwight H. Chiang, Chienwei Li, Lang Front Pharmacol Pharmacology We assessed the generalizability of machine learning methods using natural language processing (NLP) techniques to detect adverse drug events (ADEs) from clinical narratives in electronic medical records (EMRs). We constructed a new corpus correlating drugs with adverse drug events using 1,394 clinical notes of 47 randomly selected patients who received immune checkpoint inhibitors (ICIs) from 2011 to 2018 at The Ohio State University James Cancer Hospital, annotating 189 drug-ADE relations in single sentences within the medical records. We also used data from Harvard’s publicly available 2018 National Clinical Challenge (n2c2), which includes 505 discharge summaries with annotations of 1,355 single-sentence drug-ADE relations. We applied classical machine learning (support vector machine (SVM)), deep learning (convolutional neural network (CNN) and bidirectional long short-term memory (BiLSTM)), and state-of-the-art transformer-based (bidirectional encoder representations from transformers (BERT) and ClinicalBERT) methods trained and tested in the two different corpora and compared performance among them to detect drug–ADE relationships. ClinicalBERT detected drug–ADE relationships better than the other methods when trained using our dataset and tested in n2c2 (ClinicalBERT F-score, 0.78; other methods, F-scores, 0.61–0.73) and when trained using the n2c2 dataset and tested in ours (ClinicalBERT F-score, 0.74; other methods, F-scores, 0.55–0.72). Comparison among several machine learning methods demonstrated the superior performance and, therefore, the greatest generalizability of findings of ClinicalBERT for the detection of drug–ADE relations from clinical narratives in electronic medical records. Frontiers Media S.A. 2023-07-12 /pmc/articles/PMC10368879/ /pubmed/37502211 http://dx.doi.org/10.3389/fphar.2023.1218679 Text en Copyright © 2023 Zitu, Zhang, Owen, Chiang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Zitu, Md Muntasir Zhang, Shijun Owen, Dwight H. Chiang, Chienwei Li, Lang Generalizability of machine learning methods in detecting adverse drug events from clinical narratives in electronic medical records |
title | Generalizability of machine learning methods in detecting adverse drug events from clinical narratives in electronic medical records |
title_full | Generalizability of machine learning methods in detecting adverse drug events from clinical narratives in electronic medical records |
title_fullStr | Generalizability of machine learning methods in detecting adverse drug events from clinical narratives in electronic medical records |
title_full_unstemmed | Generalizability of machine learning methods in detecting adverse drug events from clinical narratives in electronic medical records |
title_short | Generalizability of machine learning methods in detecting adverse drug events from clinical narratives in electronic medical records |
title_sort | generalizability of machine learning methods in detecting adverse drug events from clinical narratives in electronic medical records |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368879/ https://www.ncbi.nlm.nih.gov/pubmed/37502211 http://dx.doi.org/10.3389/fphar.2023.1218679 |
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