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Adherence to antiretroviral therapy and associated factors among human immunodeficiency -positive patients accessing treatment at health centers in East Gojjam Zone, Northwest Ethiopia, 2019: Community-based cross-sectional study
BACKGROUND: To achieve an effective treatment outcome, Antiretroviral Therapy (ART) for people living with the Human immunodeficiency virus (HIV) needs at least a 95% adherence level. The aim was to assess adherence to antiretroviral therapy and its associated factors among patients accessing treatm...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368896/ https://www.ncbi.nlm.nih.gov/pubmed/37501982 http://dx.doi.org/10.1016/j.heliyon.2023.e18279 |
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author | Tariku, Mengistie Kassahun Worede, Daniel Tarekegn Belete, Abebe Habtamu |
author_facet | Tariku, Mengistie Kassahun Worede, Daniel Tarekegn Belete, Abebe Habtamu |
author_sort | Tariku, Mengistie Kassahun |
collection | PubMed |
description | BACKGROUND: To achieve an effective treatment outcome, Antiretroviral Therapy (ART) for people living with the Human immunodeficiency virus (HIV) needs at least a 95% adherence level. The aim was to assess adherence to antiretroviral therapy and its associated factors among patients accessing treatment at Health centers in East Gojjam Zone, Northwest Ethiopia. METHODS: A community-based cross-sectional study was conducted on 770 HIV-positive patients from April 1 to May 10, 2019, in East Gojjam Zone. The study participants were selected by simple random computerized sampling methods. Primary data was collected from the patients through face-to-face interviews and home-to-home visits. Bivariable and multivariable binary logistic regression analyses were done. Independent variables with a P-value of <0.2 in bivariable binary logistic regression analysis were considered for multivariable binary logistic regression analysis. A P-value of <0.05 was used as the cut-off point for the presence of statistical significance. RESULTS: About 396 (51.8%) of the study participants had good adherence. Being 18–24 years old [Adjusted Odd Ratio (AOR) = 0.43; 95% CI = 0.21–0.86], having a marital status of being widowed (AOR = 0.29; 95% CI = 0.14–0.58), having a disease duration of >10 years (AOR = 0.47; 95% CI = 0.24–0.94), taking a drug regimen of Tenofovir (TDF) + Lamivudine (3 TC) + Nevirapine (NVP) (AOR = 2.94; 95% CI = 1.406.15), not being socially stigmatized (AOR = 0.52; 95% CI = 0.34–0.78), and having not encountered an opportunistic infection (AOR = 3.91; 95% CI = 2.68–5.72) were significant factors. CONCLUSIONS: The level of adherence was low. Opportunistic infection prevention, reduction of social stigma, and other intervention activities should be strengthened to increase the level of adherence. |
format | Online Article Text |
id | pubmed-10368896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103688962023-07-27 Adherence to antiretroviral therapy and associated factors among human immunodeficiency -positive patients accessing treatment at health centers in East Gojjam Zone, Northwest Ethiopia, 2019: Community-based cross-sectional study Tariku, Mengistie Kassahun Worede, Daniel Tarekegn Belete, Abebe Habtamu Heliyon Research Article BACKGROUND: To achieve an effective treatment outcome, Antiretroviral Therapy (ART) for people living with the Human immunodeficiency virus (HIV) needs at least a 95% adherence level. The aim was to assess adherence to antiretroviral therapy and its associated factors among patients accessing treatment at Health centers in East Gojjam Zone, Northwest Ethiopia. METHODS: A community-based cross-sectional study was conducted on 770 HIV-positive patients from April 1 to May 10, 2019, in East Gojjam Zone. The study participants were selected by simple random computerized sampling methods. Primary data was collected from the patients through face-to-face interviews and home-to-home visits. Bivariable and multivariable binary logistic regression analyses were done. Independent variables with a P-value of <0.2 in bivariable binary logistic regression analysis were considered for multivariable binary logistic regression analysis. A P-value of <0.05 was used as the cut-off point for the presence of statistical significance. RESULTS: About 396 (51.8%) of the study participants had good adherence. Being 18–24 years old [Adjusted Odd Ratio (AOR) = 0.43; 95% CI = 0.21–0.86], having a marital status of being widowed (AOR = 0.29; 95% CI = 0.14–0.58), having a disease duration of >10 years (AOR = 0.47; 95% CI = 0.24–0.94), taking a drug regimen of Tenofovir (TDF) + Lamivudine (3 TC) + Nevirapine (NVP) (AOR = 2.94; 95% CI = 1.406.15), not being socially stigmatized (AOR = 0.52; 95% CI = 0.34–0.78), and having not encountered an opportunistic infection (AOR = 3.91; 95% CI = 2.68–5.72) were significant factors. CONCLUSIONS: The level of adherence was low. Opportunistic infection prevention, reduction of social stigma, and other intervention activities should be strengthened to increase the level of adherence. Elsevier 2023-07-13 /pmc/articles/PMC10368896/ /pubmed/37501982 http://dx.doi.org/10.1016/j.heliyon.2023.e18279 Text en © 2023 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Tariku, Mengistie Kassahun Worede, Daniel Tarekegn Belete, Abebe Habtamu Adherence to antiretroviral therapy and associated factors among human immunodeficiency -positive patients accessing treatment at health centers in East Gojjam Zone, Northwest Ethiopia, 2019: Community-based cross-sectional study |
title | Adherence to antiretroviral therapy and associated factors among human immunodeficiency -positive patients accessing treatment at health centers in East Gojjam Zone, Northwest Ethiopia, 2019: Community-based cross-sectional study |
title_full | Adherence to antiretroviral therapy and associated factors among human immunodeficiency -positive patients accessing treatment at health centers in East Gojjam Zone, Northwest Ethiopia, 2019: Community-based cross-sectional study |
title_fullStr | Adherence to antiretroviral therapy and associated factors among human immunodeficiency -positive patients accessing treatment at health centers in East Gojjam Zone, Northwest Ethiopia, 2019: Community-based cross-sectional study |
title_full_unstemmed | Adherence to antiretroviral therapy and associated factors among human immunodeficiency -positive patients accessing treatment at health centers in East Gojjam Zone, Northwest Ethiopia, 2019: Community-based cross-sectional study |
title_short | Adherence to antiretroviral therapy and associated factors among human immunodeficiency -positive patients accessing treatment at health centers in East Gojjam Zone, Northwest Ethiopia, 2019: Community-based cross-sectional study |
title_sort | adherence to antiretroviral therapy and associated factors among human immunodeficiency -positive patients accessing treatment at health centers in east gojjam zone, northwest ethiopia, 2019: community-based cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368896/ https://www.ncbi.nlm.nih.gov/pubmed/37501982 http://dx.doi.org/10.1016/j.heliyon.2023.e18279 |
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