Binding modes of potential anti-prion phytochemicals to PrP(C) structures in silico

BACKGROUND: Prion diseases involve the conversion of a normal, cell-surface glycoprotein (PrP(C)) into a misfolded pathogenic form (PrP(Sc)). One possible strategy to inhibit PrP(Sc) formation is to stabilize the native conformation of PrP(C) and interfere with the conversion of PrP(C) to PrP(Sc). M...

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Detalles Bibliográficos
Autores principales: Neupane, Sandesh, Khadka, Jenisha, Rayamajhi, Sandesh, Pandey, Arti S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368899/
https://www.ncbi.nlm.nih.gov/pubmed/37453159
http://dx.doi.org/10.1016/j.jaim.2023.100750

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