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Bullous herpes zoster masquerading as a bullous pemphigoid flare: A case report

Herpes zoster (HZ) results from the reactivation of dormant varicella zoster virus (VZV) in the posterior dorsal root ganglia manifesting as painful vesicles along the dermatomal distribution as shingles. The risk of reactivation is higher in immunocompromised patients. Herpes zoster lesions can hav...

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Detalles Bibliográficos
Autores principales: Shehadah, Ahmed, Yousef, Alshaima, Hashem, Anas, Mahmoud, Amir A., Aggarwal, Abhimanyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368929/
https://www.ncbi.nlm.nih.gov/pubmed/37502653
http://dx.doi.org/10.1016/j.idcr.2023.e01846
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author Shehadah, Ahmed
Yousef, Alshaima
Hashem, Anas
Mahmoud, Amir A.
Aggarwal, Abhimanyu
author_facet Shehadah, Ahmed
Yousef, Alshaima
Hashem, Anas
Mahmoud, Amir A.
Aggarwal, Abhimanyu
author_sort Shehadah, Ahmed
collection PubMed
description Herpes zoster (HZ) results from the reactivation of dormant varicella zoster virus (VZV) in the posterior dorsal root ganglia manifesting as painful vesicles along the dermatomal distribution as shingles. The risk of reactivation is higher in immunocompromised patients. Herpes zoster lesions can have varied presentations including bullous forms, may induce BP flare, may co-exist in the same lesions, and should be included in the list of differentials for BP flares not responding to the standard of care. Here, we describe a case of a 74-year-old female with a history of recurrent bullous pemphigoid (BP) flares, who was on mycophenolate mofetil, and presented with skin lesions on her right thigh which were typical for her BP flares. Unlike prior flares, the lesions did not respond to prednisone therapy. Her hospitalization course was complicated by encephalopathy. Intravenous acyclovir was started empirically. Viral cultures and polymerase chain reaction from the lesions came back positive for VZV, but the patient succumbed to her illness shortly afterward.
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spelling pubmed-103689292023-07-27 Bullous herpes zoster masquerading as a bullous pemphigoid flare: A case report Shehadah, Ahmed Yousef, Alshaima Hashem, Anas Mahmoud, Amir A. Aggarwal, Abhimanyu IDCases Case Report Herpes zoster (HZ) results from the reactivation of dormant varicella zoster virus (VZV) in the posterior dorsal root ganglia manifesting as painful vesicles along the dermatomal distribution as shingles. The risk of reactivation is higher in immunocompromised patients. Herpes zoster lesions can have varied presentations including bullous forms, may induce BP flare, may co-exist in the same lesions, and should be included in the list of differentials for BP flares not responding to the standard of care. Here, we describe a case of a 74-year-old female with a history of recurrent bullous pemphigoid (BP) flares, who was on mycophenolate mofetil, and presented with skin lesions on her right thigh which were typical for her BP flares. Unlike prior flares, the lesions did not respond to prednisone therapy. Her hospitalization course was complicated by encephalopathy. Intravenous acyclovir was started empirically. Viral cultures and polymerase chain reaction from the lesions came back positive for VZV, but the patient succumbed to her illness shortly afterward. Elsevier 2023-07-07 /pmc/articles/PMC10368929/ /pubmed/37502653 http://dx.doi.org/10.1016/j.idcr.2023.e01846 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Shehadah, Ahmed
Yousef, Alshaima
Hashem, Anas
Mahmoud, Amir A.
Aggarwal, Abhimanyu
Bullous herpes zoster masquerading as a bullous pemphigoid flare: A case report
title Bullous herpes zoster masquerading as a bullous pemphigoid flare: A case report
title_full Bullous herpes zoster masquerading as a bullous pemphigoid flare: A case report
title_fullStr Bullous herpes zoster masquerading as a bullous pemphigoid flare: A case report
title_full_unstemmed Bullous herpes zoster masquerading as a bullous pemphigoid flare: A case report
title_short Bullous herpes zoster masquerading as a bullous pemphigoid flare: A case report
title_sort bullous herpes zoster masquerading as a bullous pemphigoid flare: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368929/
https://www.ncbi.nlm.nih.gov/pubmed/37502653
http://dx.doi.org/10.1016/j.idcr.2023.e01846
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