Superspreading of SARS-CoV-2 Omicron BA.2.23 among vaccinated Finnish adults: symptomatic COVID-19 only contracted by those without recent infection

An outbreak of SARS-CoV-2 was confirmed after an academic party in Helsinki, Finland, in 2022. All 70 guests were requested to fill in follow-up questionnaires; serologic analyses and whole-genome sequencing (WGS) were conducted when possible. Of those participating – all but one with ≥3 vaccine dos...

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Detalles Bibliográficos
Autores principales: Riekkinen, Marianna, Kajova, Mikael, Eriksson, Mari, Luukkainen, Annika, Holmberg, Ville, Aro, Tuomas, Pakkanen, Sari H, Miettinen, Simo, Montonen, Reetta, Smura, Teemu, Lääveri, Tinja, Kantele, Anu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
From the Field
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10368952/
https://www.ncbi.nlm.nih.gov/pubmed/37401478
http://dx.doi.org/10.1017/S0950268823001024
Descripción
Sumario:An outbreak of SARS-CoV-2 was confirmed after an academic party in Helsinki, Finland, in 2022. All 70 guests were requested to fill in follow-up questionnaires; serologic analyses and whole-genome sequencing (WGS) were conducted when possible. Of those participating – all but one with ≥3 vaccine doses – 21/53 (40%) had test-confirmed symptomatic COVID-19: 7% of those with earlier episodes and 76% of those without. Half (11/21) were febrile, but none needed hospitalisation. WGS revealed subvariant BA.2.23. Compared to vaccination alone, our data suggest remarkable protection by hybrid immunity against symptomatic infection, particularly in instances of recent infections with homologous variants.

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