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Multiple breath washout and oscillometry after allogenic HSCT: a scoping review

Pulmonary chronic graft-versus-host disease (cGVHD) is a substantial cause of pulmonary morbidity and mortality post-haematopoietic stem cell transplantation (HSCT). Current spirometry-based monitoring strategies have significant limitations. Understanding the utility of novel peripheral airway func...

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Autores principales: Sonneveld, Nicole, Rayment, Jonathan H., Usemann, Jakob, Nielsen, Kim G., Robinson, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369167/
https://www.ncbi.nlm.nih.gov/pubmed/37495248
http://dx.doi.org/10.1183/16000617.0251-2022
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author Sonneveld, Nicole
Rayment, Jonathan H.
Usemann, Jakob
Nielsen, Kim G.
Robinson, Paul D.
author_facet Sonneveld, Nicole
Rayment, Jonathan H.
Usemann, Jakob
Nielsen, Kim G.
Robinson, Paul D.
author_sort Sonneveld, Nicole
collection PubMed
description Pulmonary chronic graft-versus-host disease (cGVHD) is a substantial cause of pulmonary morbidity and mortality post-haematopoietic stem cell transplantation (HSCT). Current spirometry-based monitoring strategies have significant limitations. Understanding the utility of novel peripheral airway function tests – multiple breath washout (MBW) and oscillometry – is critical in efforts to improve detection, facilitate earlier intervention and improve outcomes. In this scoping review, we identified 17 studies investigating MBW or oscillometry, or both, after allogenic HSCT. Despite small study numbers limiting the ability to draw firm conclusions, several themes were evident. Detectable peripheral airway abnormality in MBW occurred in a substantial proportion prior to HSCT. MBW indices post-HSCT were more frequently abnormal than spirometry when reporting group data and among those with extrapulmonary cGVHD and pulmonary cGVHD. Changes in MBW indices over time may be more indicative of pulmonary complications than absolute values at any given time point. Oscillometry indices were often normal at baseline, but more frequently abnormal in those who developed pulmonary cGVHD. Pooling currently available individual participant data across these studies may improve our ability to formally compare their respective sensitivity and specificity at specific time points and assess the trajectory of MBW and oscillometry indices over time.
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spelling pubmed-103691672023-07-27 Multiple breath washout and oscillometry after allogenic HSCT: a scoping review Sonneveld, Nicole Rayment, Jonathan H. Usemann, Jakob Nielsen, Kim G. Robinson, Paul D. Eur Respir Rev Reviews Pulmonary chronic graft-versus-host disease (cGVHD) is a substantial cause of pulmonary morbidity and mortality post-haematopoietic stem cell transplantation (HSCT). Current spirometry-based monitoring strategies have significant limitations. Understanding the utility of novel peripheral airway function tests – multiple breath washout (MBW) and oscillometry – is critical in efforts to improve detection, facilitate earlier intervention and improve outcomes. In this scoping review, we identified 17 studies investigating MBW or oscillometry, or both, after allogenic HSCT. Despite small study numbers limiting the ability to draw firm conclusions, several themes were evident. Detectable peripheral airway abnormality in MBW occurred in a substantial proportion prior to HSCT. MBW indices post-HSCT were more frequently abnormal than spirometry when reporting group data and among those with extrapulmonary cGVHD and pulmonary cGVHD. Changes in MBW indices over time may be more indicative of pulmonary complications than absolute values at any given time point. Oscillometry indices were often normal at baseline, but more frequently abnormal in those who developed pulmonary cGVHD. Pooling currently available individual participant data across these studies may improve our ability to formally compare their respective sensitivity and specificity at specific time points and assess the trajectory of MBW and oscillometry indices over time. European Respiratory Society 2023-07-26 /pmc/articles/PMC10369167/ /pubmed/37495248 http://dx.doi.org/10.1183/16000617.0251-2022 Text en Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Reviews
Sonneveld, Nicole
Rayment, Jonathan H.
Usemann, Jakob
Nielsen, Kim G.
Robinson, Paul D.
Multiple breath washout and oscillometry after allogenic HSCT: a scoping review
title Multiple breath washout and oscillometry after allogenic HSCT: a scoping review
title_full Multiple breath washout and oscillometry after allogenic HSCT: a scoping review
title_fullStr Multiple breath washout and oscillometry after allogenic HSCT: a scoping review
title_full_unstemmed Multiple breath washout and oscillometry after allogenic HSCT: a scoping review
title_short Multiple breath washout and oscillometry after allogenic HSCT: a scoping review
title_sort multiple breath washout and oscillometry after allogenic hsct: a scoping review
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369167/
https://www.ncbi.nlm.nih.gov/pubmed/37495248
http://dx.doi.org/10.1183/16000617.0251-2022
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