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3D bioprinting—a model for skin aging

Human lifespan continues to extend as an unprecedented number of people reach their seventh and eighth decades of life, unveiling chronic conditions that affect the older adult. Age-related skin conditions include senile purpura, seborrheic keratoses, pemphigus vulgaris, bullous pemphigoid, diabetic...

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Autores principales: Ansaf, Ryeim B, Ziebart, Rachel, Gudapati, Hemanth, Simoes Torigoe, Rafaela Mayumi, Victorelli, Stella, Passos, Joao, Wyles, Saranya P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369216/
https://www.ncbi.nlm.nih.gov/pubmed/37501679
http://dx.doi.org/10.1093/rb/rbad060
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author Ansaf, Ryeim B
Ziebart, Rachel
Gudapati, Hemanth
Simoes Torigoe, Rafaela Mayumi
Victorelli, Stella
Passos, Joao
Wyles, Saranya P
author_facet Ansaf, Ryeim B
Ziebart, Rachel
Gudapati, Hemanth
Simoes Torigoe, Rafaela Mayumi
Victorelli, Stella
Passos, Joao
Wyles, Saranya P
author_sort Ansaf, Ryeim B
collection PubMed
description Human lifespan continues to extend as an unprecedented number of people reach their seventh and eighth decades of life, unveiling chronic conditions that affect the older adult. Age-related skin conditions include senile purpura, seborrheic keratoses, pemphigus vulgaris, bullous pemphigoid, diabetic foot wounds and skin cancer. Current methods of drug testing prior to clinical trials require the use of pre-clinical animal models, which are often unable to adequately replicate human skin response. Therefore, a reliable model for aged human skin is needed. The current challenges in developing an aged human skin model include the intrinsic variability in skin architecture from person to person. An ideal skin model would incorporate innate functionality such as sensation, vascularization and regeneration. The advent of 3D bioprinting allows us to create human skin equivalent for use as clinical-grade surgical graft, for drug testing and other needs. In this review, we describe the process of human skin aging and outline the steps to create an aged skin model with 3D bioprinting using skin cells (i.e. keratinocytes, fibroblasts and melanocytes). We also provide an overview of current bioprinted skin models, associated limitations and direction for future research.
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spelling pubmed-103692162023-07-27 3D bioprinting—a model for skin aging Ansaf, Ryeim B Ziebart, Rachel Gudapati, Hemanth Simoes Torigoe, Rafaela Mayumi Victorelli, Stella Passos, Joao Wyles, Saranya P Regen Biomater Review Human lifespan continues to extend as an unprecedented number of people reach their seventh and eighth decades of life, unveiling chronic conditions that affect the older adult. Age-related skin conditions include senile purpura, seborrheic keratoses, pemphigus vulgaris, bullous pemphigoid, diabetic foot wounds and skin cancer. Current methods of drug testing prior to clinical trials require the use of pre-clinical animal models, which are often unable to adequately replicate human skin response. Therefore, a reliable model for aged human skin is needed. The current challenges in developing an aged human skin model include the intrinsic variability in skin architecture from person to person. An ideal skin model would incorporate innate functionality such as sensation, vascularization and regeneration. The advent of 3D bioprinting allows us to create human skin equivalent for use as clinical-grade surgical graft, for drug testing and other needs. In this review, we describe the process of human skin aging and outline the steps to create an aged skin model with 3D bioprinting using skin cells (i.e. keratinocytes, fibroblasts and melanocytes). We also provide an overview of current bioprinted skin models, associated limitations and direction for future research. Oxford University Press 2023-06-13 /pmc/articles/PMC10369216/ /pubmed/37501679 http://dx.doi.org/10.1093/rb/rbad060 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Ansaf, Ryeim B
Ziebart, Rachel
Gudapati, Hemanth
Simoes Torigoe, Rafaela Mayumi
Victorelli, Stella
Passos, Joao
Wyles, Saranya P
3D bioprinting—a model for skin aging
title 3D bioprinting—a model for skin aging
title_full 3D bioprinting—a model for skin aging
title_fullStr 3D bioprinting—a model for skin aging
title_full_unstemmed 3D bioprinting—a model for skin aging
title_short 3D bioprinting—a model for skin aging
title_sort 3d bioprinting—a model for skin aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369216/
https://www.ncbi.nlm.nih.gov/pubmed/37501679
http://dx.doi.org/10.1093/rb/rbad060
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