Exeporfinium chloride (XF-73) nasal gel dosed over 24 hours prior to surgery significantly reduced Staphylococcus aureus nasal carriage in cardiac surgery patients: Safety and efficacy results from a randomized placebo-controlled phase 2 study

We studied 83 cardiac-surgery patients with nasal S. aureus carriage who received 4 intranasal administrations of XF-73 nasal gel or placebo <24 hours before surgery. One hour before surgery, patients exhibited a S. aureus nasal carriage reduction of 2.5 log(10) with XF-73 compared to 0.4 log(10)...

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Detalles Bibliográficos
Autores principales: Mangino, Julie E., Firstenberg, Michael S., Milewski, Rita K.C., Rhys-Williams, William, Lees, James P., Dane, Aaron, Love, William G., Gonzalez Moreno, Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Concise Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369221/
https://www.ncbi.nlm.nih.gov/pubmed/36951472
http://dx.doi.org/10.1017/ice.2023.17

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