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YBX1‐Mediated DNA Methylation‐Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia (Adv. Sci. 20/2023)
Developing Cortical Interneuronsin Schizophrenia The elusive human brain is much like the unattainable sun, and there is no directly feasible approach to understand how the brain is disturbed during the development of schizophrenia. As the shimmering sun's reflection in the water, brain organoi...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369229/ http://dx.doi.org/10.1002/advs.202370132 |
| _version_ | 1785077712422961152 |
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| author | Ni, Peiyan Zhou, Chuqing Liang, Sugai Jiang, Youhui Liu, Dongxin Shao, Zhicheng Noh, Haneul Zhao, Liansheng Tian, Yang Zhang, Chengcheng Wei, Jinxue Li, Xiaojing Yu, Hua Ni, Rongjun Yu, Xueli Qi, Xueyu Zhang, Yamin Ma, Xiaohong Deng, Wei Guo, Wanjun Wang, Qiang Sham, Pak C. Chung, Sangmi Li, Tao |
| author_facet | Ni, Peiyan Zhou, Chuqing Liang, Sugai Jiang, Youhui Liu, Dongxin Shao, Zhicheng Noh, Haneul Zhao, Liansheng Tian, Yang Zhang, Chengcheng Wei, Jinxue Li, Xiaojing Yu, Hua Ni, Rongjun Yu, Xueli Qi, Xueyu Zhang, Yamin Ma, Xiaohong Deng, Wei Guo, Wanjun Wang, Qiang Sham, Pak C. Chung, Sangmi Li, Tao |
| author_sort | Ni, Peiyan |
| collection | PubMed |
| description | Developing Cortical Interneuronsin Schizophrenia The elusive human brain is much like the unattainable sun, and there is no directly feasible approach to understand how the brain is disturbed during the development of schizophrenia. As the shimmering sun's reflection in the water, brain organoid provides an accessible bridge to explore the mysteries of the human brain. In article number 2300455, Peiyan Ni, Chuqing Zhou, Sangmi Chung, and co‐workers confirm the hypermethylation and dysregulated expression of SHANK3 in schizophrenia patient‐derived cortical interneurons‐rich organoid, which serves as a bridge to explore the pathological changes in the brain by measuring SHANK3 methylation in peripheral blood mononuclear cells as a biomarker. [Image: see text] |
| format | Online Article Text |
| id | pubmed-10369229 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103692292023-07-27 YBX1‐Mediated DNA Methylation‐Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia (Adv. Sci. 20/2023) Ni, Peiyan Zhou, Chuqing Liang, Sugai Jiang, Youhui Liu, Dongxin Shao, Zhicheng Noh, Haneul Zhao, Liansheng Tian, Yang Zhang, Chengcheng Wei, Jinxue Li, Xiaojing Yu, Hua Ni, Rongjun Yu, Xueli Qi, Xueyu Zhang, Yamin Ma, Xiaohong Deng, Wei Guo, Wanjun Wang, Qiang Sham, Pak C. Chung, Sangmi Li, Tao Adv Sci (Weinh) Inside Back Cover Developing Cortical Interneuronsin Schizophrenia The elusive human brain is much like the unattainable sun, and there is no directly feasible approach to understand how the brain is disturbed during the development of schizophrenia. As the shimmering sun's reflection in the water, brain organoid provides an accessible bridge to explore the mysteries of the human brain. In article number 2300455, Peiyan Ni, Chuqing Zhou, Sangmi Chung, and co‐workers confirm the hypermethylation and dysregulated expression of SHANK3 in schizophrenia patient‐derived cortical interneurons‐rich organoid, which serves as a bridge to explore the pathological changes in the brain by measuring SHANK3 methylation in peripheral blood mononuclear cells as a biomarker. [Image: see text] John Wiley and Sons Inc. 2023-07-26 /pmc/articles/PMC10369229/ http://dx.doi.org/10.1002/advs.202370132 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Inside Back Cover Ni, Peiyan Zhou, Chuqing Liang, Sugai Jiang, Youhui Liu, Dongxin Shao, Zhicheng Noh, Haneul Zhao, Liansheng Tian, Yang Zhang, Chengcheng Wei, Jinxue Li, Xiaojing Yu, Hua Ni, Rongjun Yu, Xueli Qi, Xueyu Zhang, Yamin Ma, Xiaohong Deng, Wei Guo, Wanjun Wang, Qiang Sham, Pak C. Chung, Sangmi Li, Tao YBX1‐Mediated DNA Methylation‐Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia (Adv. Sci. 20/2023) |
| title | YBX1‐Mediated DNA Methylation‐Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia (Adv. Sci. 20/2023) |
| title_full | YBX1‐Mediated DNA Methylation‐Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia (Adv. Sci. 20/2023) |
| title_fullStr | YBX1‐Mediated DNA Methylation‐Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia (Adv. Sci. 20/2023) |
| title_full_unstemmed | YBX1‐Mediated DNA Methylation‐Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia (Adv. Sci. 20/2023) |
| title_short | YBX1‐Mediated DNA Methylation‐Dependent SHANK3 Expression in PBMCs and Developing Cortical Interneurons in Schizophrenia (Adv. Sci. 20/2023) |
| title_sort | ybx1‐mediated dna methylation‐dependent shank3 expression in pbmcs and developing cortical interneurons in schizophrenia (adv. sci. 20/2023) |
| topic | Inside Back Cover |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369229/ http://dx.doi.org/10.1002/advs.202370132 |
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