Cargando…

Transplanting Human Neural Stem Cells with ≈50% Reduction of SOX9 Gene Dosage Promotes Tissue Repair and Functional Recovery from Severe Spinal Cord Injury

Neural stem cells (NSCs) derived from human pluripotent stem cells (hPSCs) are considered a major cell source for reconstructing damaged neural circuitry and enabling axonal regeneration. However, the microenvironment at the site of spinal cord injury (SCI) and inadequate intrinsic factors limit the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jessica Aijia, Tam, Kin Wai, Chen, Yong Long, Feng, Xianglan, Chan, Christy Wing Lam, Lo, Amos Lok Hang, Wu, Kenneth Lap‐Kei, Hui, Man‐Ning, Wu, Ming‐Hoi, Chan, Ken Kwok‐Keung, Cheung, May Pui Lai, Cheung, Chi Wai, Shum, Daisy Kwok‐Yan, Chan, Ying‐Shing, Cheung, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369238/ https://www.ncbi.nlm.nih.gov/pubmed/37296073 http://dx.doi.org/10.1002/advs.202205804

Ejemplares similares

Derivation of Oligodendrocyte Precursors from Adult Bone Marrow Stromal Cells for Remyelination Therapy
por: Tsui, Yat-Ping, et al.
Publicado: (2021)

Fbxo9 functions downstream of Sox10 to determine neuron-glial fate choice in the dorsal root ganglia through Neurog2 destabilization
por: Liu, Jessica Aijia, et al.
Publicado: (2020)

The Role of microRNAs in Ovarian Granulosa Cells in Health and Disease
por: Tu, Jiajie, et al.
Publicado: (2019)

Superiority of Multiple-Joint Space Width over Minimum-Joint Space Width Approach in the Machine Learning for Radiographic Severity and Knee Osteoarthritis Progression
por: Cheung, James Chung-Wai, et al.
Publicado: (2021)

SOX9 is a dose-dependent metastatic fate determinant in melanoma
por: Yang, Xintao, et al.
Publicado: (2019)

IPSC-Derived Sensory Neurons Directing Fate Commitment of Human BMSC-Derived Schwann Cells: Applications in Traumatic Neural Injuries
por: Tam, Kin-Wai, et al.
Publicado: (2023)

microRNA-126 Is a Tumor Suppressor of Granulosa Cell Tumor Mediated by Its Host Gene EGFL7
por: Tu, Jiajie, et al.
Publicado: (2019)

Hypermethylation of genes in testicular embryonal carcinomas
por: Cheung, Hoi-Hung, et al.
Publicado: (2016)

Molecular Mechanisms of Regulation and Action of microRNA-199a in Testicular Germ Cell Tumor and Glioblastomas
por: Gu, Shen, et al.
Publicado: (2013)

Propofol total intravenous anaesthesia versus inhalational anaesthesia for acute postoperative pain in patients with morphine patient-controlled analgesia: a large-scale retrospective study with covariate adjustment
por: Wong, Stanley Sau Ching, et al.
Publicado: (2022)

Lessons learnt from the impact of COVID-19 on arthroplasty services in Hong Kong: how to prepare for the next pandemic?
por: Lee, Lok Sze, et al.
Publicado: (2021)

Directed Differentiation of Human Bone Marrow Stromal Cells to Fate-Committed Schwann Cells
por: Cai, Sa, et al.
Publicado: (2017)

Robotic-Arm Assistance Simplifies Hip Arthrodesis Conversion to Total Hip Arthroplasty
por: Fu, Henry, et al.
Publicado: (2020)

How well do elderly patients do after total knee arthroplasty in the era of fast-track surgery?
por: Cheung, Amy, et al.
Publicado: (2020)

Artificial intelligence in diagnosis of knee osteoarthritis and prediction of arthroplasty outcomes: a review
por: Lee, Lok Sze, et al.
Publicado: (2022)

Consensus statements on the management of clinically localized prostate cancer from the Hong Kong Urological Association and the Hong Kong Society of Uro‐Oncology
por: Ma, Wai‐Kit, et al.
Publicado: (2019)

Stem cell aging in adult progeria
por: Cheung, Hoi-Hung, et al.
Publicado: (2015)

Robotic arm-assisted unicondylar knee arthroplasty resulted in superior radiological accuracy: a propensity score-matched analysis
por: Yeung, Matthew H. Y., et al.
Publicado: (2023)

Comprehensive characterization of the patient-derived xenograft and the paralleled primary hepatocellular carcinoma cell line
por: Cheung, Phyllis F. Y., et al.
Publicado: (2016)

Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors in rats: role in coding linear accelerations
por: Li, Chuan, et al.
Publicado: (2012)

Validation of Diagnostic Coding for Asthma in an Electronic Health Record System in Hong Kong
por: Kwok, Wang Chun, et al.
Publicado: (2023)

Use of a modular hip dual-mobility articulation in patients with high risk of dislocation: a relatively small-sized acetabulum in Asian patients may limit its use
por: Chan, Ping Keung, et al.
Publicado: (2021)

The application of close incisional negative pressure wound therapy in revision arthroplasty among asian patients: a comparative study
por: Chan, Ping Keung, et al.
Publicado: (2021)

Association between Recent Usage of Antibiotics and Immunogenicity within Six Months after COVID-19 Vaccination
por: Cheung, Ka-Shing, et al.
Publicado: (2022)

Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons
por: Kwok, Jessica CF, et al.
Publicado: (2012)

Human Induced Pluripotent Cell‐Derived Sensory Neurons for Fate Commitment of Bone Marrow‐Derived Schwann Cells: Implications for Remyelination Therapy
por: Cai, Sa, et al.
Publicado: (2016)

Management of Intestinal Strictures Post Conservative Treatment of Necrotizing Enterocolitis: The Long Term Outcome
por: Houben, Christoph Heinrich, et al.
Publicado: (2016)

GermSAGE: a comprehensive SAGE database for transcript discovery on male germ cell development
por: Lee, Tin-Lap, et al.
Publicado: (2009)

The role of telemedicine in joint replacement surgery? An updated review
por: Li, Ka Yau, et al.
Publicado: (2023)

Reduction of psycho-spiritual distress of an elderly with advanced congestive heart failure by life review interview in a palliative care day center
por: Chan, Kwok-Ying, et al.
Publicado: (2016)

Effect of moderate-to-severe hepatic steatosis on neutralising antibody response among BNT162b2 and CoronaVac recipients
por: Cheung, Ka Shing, et al.
Publicado: (2022)

Antibiotics Associated with Lower Survival in Hepatocellular Cancer Patients Receiving Immune Checkpoint Inhibitors Independent of Tumor Status
por: Cheung, Ka Shing, et al.
Publicado: (2022)

Immune-Related Endocrine Dysfunctions in Combined Modalities of Treatment: Real-World Data
por: Chan, Wing-Lok, et al.
Publicado: (2021)

Risk of community-acquired pneumonia requiring hospitalization in patients with spondyloarthritis
por: Chung, Ho Yin, et al.
Publicado: (2020)

The effectiveness of low-dose desmopressin in improving hypothermia-induced impairment of primary haemostasis under influence of aspirin – a randomized controlled trial
por: Tsui, Pui Yee, et al.
Publicado: (2015)

Hypericin and Pheophorbide a Mediated Photodynamic Therapy Fighting MRSA Wound Infections: A Translational Study from In Vitro to In Vivo
por: Chan, Ben Chung Lap, et al.
Publicado: (2021)

Prenatal sonography of placental abscess and prolonged antibiotic treatment for Serratia marcescens bacteremia
por: Mak, Annisa Shui Lam, et al.
Publicado: (2018)

Immune Actions on the Peripheral Nervous System in Pain
por: Liu, Jessica Aijia, et al.
Publicado: (2021)

Influence of autophagy on the efficacy of radiotherapy
por: Tam, Shing Yau, et al.
Publicado: (2017)

A Chinese Chan-based Mind-Body Intervention Improves Memory of Older Adults
por: Chan, Agnes S., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_l4t2sejl8mup62iiil0rlm5io8