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Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities
Liposomes have received tremendous attention as a class of versatile pharmaceutical vehicles of great potential over the past several decades. However, the application of liposomes encounters major challenges due to the knowledge gaps in their in vivo delivery process. Immunoglobulin M (IgM) display...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369250/ https://www.ncbi.nlm.nih.gov/pubmed/37150860 http://dx.doi.org/10.1002/advs.202301777 |
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author | Wang, Huan Lin, Shiqi Wu, Xiying Jiang, Kuan Lu, Huiping Zhan, Changyou |
author_facet | Wang, Huan Lin, Shiqi Wu, Xiying Jiang, Kuan Lu, Huiping Zhan, Changyou |
author_sort | Wang, Huan |
collection | PubMed |
description | Liposomes have received tremendous attention as a class of versatile pharmaceutical vehicles of great potential over the past several decades. However, the application of liposomes encounters major challenges due to the knowledge gaps in their in vivo delivery process. Immunoglobulin M (IgM) displays both pervasiveness and complexity in regulating the biological functions as well as eliciting adverse effects of liposomes. Understanding, mitigating, and exploiting the duality of IgM are prerequisites for achieving various biomedical applications of liposomes. In this review, the intricate relationship between liposomes and their biological environments has been summarized, with an emphasis on the regulatory effects of IgM on in vivo performance of liposomes. Corresponding solutions have also been discussed to evade IgM‐mediated opsonization for safe and efficient drug delivery. |
format | Online Article Text |
id | pubmed-10369250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103692502023-07-27 Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities Wang, Huan Lin, Shiqi Wu, Xiying Jiang, Kuan Lu, Huiping Zhan, Changyou Adv Sci (Weinh) Reviews Liposomes have received tremendous attention as a class of versatile pharmaceutical vehicles of great potential over the past several decades. However, the application of liposomes encounters major challenges due to the knowledge gaps in their in vivo delivery process. Immunoglobulin M (IgM) displays both pervasiveness and complexity in regulating the biological functions as well as eliciting adverse effects of liposomes. Understanding, mitigating, and exploiting the duality of IgM are prerequisites for achieving various biomedical applications of liposomes. In this review, the intricate relationship between liposomes and their biological environments has been summarized, with an emphasis on the regulatory effects of IgM on in vivo performance of liposomes. Corresponding solutions have also been discussed to evade IgM‐mediated opsonization for safe and efficient drug delivery. John Wiley and Sons Inc. 2023-05-07 /pmc/articles/PMC10369250/ /pubmed/37150860 http://dx.doi.org/10.1002/advs.202301777 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Wang, Huan Lin, Shiqi Wu, Xiying Jiang, Kuan Lu, Huiping Zhan, Changyou Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities |
title | Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities |
title_full | Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities |
title_fullStr | Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities |
title_full_unstemmed | Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities |
title_short | Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities |
title_sort | interplay between liposomes and igm: principles, challenges, and opportunities |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369250/ https://www.ncbi.nlm.nih.gov/pubmed/37150860 http://dx.doi.org/10.1002/advs.202301777 |
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