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Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities

Liposomes have received tremendous attention as a class of versatile pharmaceutical vehicles of great potential over the past several decades. However, the application of liposomes encounters major challenges due to the knowledge gaps in their in vivo delivery process. Immunoglobulin M (IgM) display...

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Autores principales: Wang, Huan, Lin, Shiqi, Wu, Xiying, Jiang, Kuan, Lu, Huiping, Zhan, Changyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369250/
https://www.ncbi.nlm.nih.gov/pubmed/37150860
http://dx.doi.org/10.1002/advs.202301777
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author Wang, Huan
Lin, Shiqi
Wu, Xiying
Jiang, Kuan
Lu, Huiping
Zhan, Changyou
author_facet Wang, Huan
Lin, Shiqi
Wu, Xiying
Jiang, Kuan
Lu, Huiping
Zhan, Changyou
author_sort Wang, Huan
collection PubMed
description Liposomes have received tremendous attention as a class of versatile pharmaceutical vehicles of great potential over the past several decades. However, the application of liposomes encounters major challenges due to the knowledge gaps in their in vivo delivery process. Immunoglobulin M (IgM) displays both pervasiveness and complexity in regulating the biological functions as well as eliciting adverse effects of liposomes. Understanding, mitigating, and exploiting the duality of IgM are prerequisites for achieving various biomedical applications of liposomes. In this review, the intricate relationship between liposomes and their biological environments has been summarized, with an emphasis on the regulatory effects of IgM on in vivo performance of liposomes. Corresponding solutions have also been discussed to evade IgM‐mediated opsonization for safe and efficient drug delivery.
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spelling pubmed-103692502023-07-27 Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities Wang, Huan Lin, Shiqi Wu, Xiying Jiang, Kuan Lu, Huiping Zhan, Changyou Adv Sci (Weinh) Reviews Liposomes have received tremendous attention as a class of versatile pharmaceutical vehicles of great potential over the past several decades. However, the application of liposomes encounters major challenges due to the knowledge gaps in their in vivo delivery process. Immunoglobulin M (IgM) displays both pervasiveness and complexity in regulating the biological functions as well as eliciting adverse effects of liposomes. Understanding, mitigating, and exploiting the duality of IgM are prerequisites for achieving various biomedical applications of liposomes. In this review, the intricate relationship between liposomes and their biological environments has been summarized, with an emphasis on the regulatory effects of IgM on in vivo performance of liposomes. Corresponding solutions have also been discussed to evade IgM‐mediated opsonization for safe and efficient drug delivery. John Wiley and Sons Inc. 2023-05-07 /pmc/articles/PMC10369250/ /pubmed/37150860 http://dx.doi.org/10.1002/advs.202301777 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Wang, Huan
Lin, Shiqi
Wu, Xiying
Jiang, Kuan
Lu, Huiping
Zhan, Changyou
Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities
title Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities
title_full Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities
title_fullStr Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities
title_full_unstemmed Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities
title_short Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities
title_sort interplay between liposomes and igm: principles, challenges, and opportunities
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369250/
https://www.ncbi.nlm.nih.gov/pubmed/37150860
http://dx.doi.org/10.1002/advs.202301777
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