PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia (Adv. Sci. 20/2023)

Tumor Microenvironment Cholesterol is the essential structural and functional component for glioma cells to maintain their biological aggressiveness. In article number 2205949, Yulong He, Yonggao Mou, Ningning Li, and co‐workers identify that excessive cholesterol excreted from IDH‐mutant glioma cel...

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Detalles Bibliográficos
Autores principales: Wang, Tao, Zhou, Yunxia, Fan, Yunping, Duan, Hao, Guo, Xiaoyu, Chang, Jinlong, Jiang, Youheng, Li, Changxue, Fu, Zhang, Gao, Yunfei, Guo, Xiaoran, Sidlauskas, Kastytis, He, Zhenqiang, Da Costa, Clive, Sheng, Xia, Wu, Dinglan, Yuan, Jinqiu, Li, Huiliang, He, Yulong, Mou, Yonggao, Li, Ningning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Inside Front Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369288/
http://dx.doi.org/10.1002/advs.202370127
Descripción
Sumario:Tumor Microenvironment Cholesterol is the essential structural and functional component for glioma cells to maintain their biological aggressiveness. In article number 2205949, Yulong He, Yonggao Mou, Ningning Li, and co‐workers identify that excessive cholesterol excreted from IDH‐mutant glioma cells, as a metabolic messenger, determines M1‐like polarization of glioma‐associated microglia/macrophage (GAMs). This study reveals that the remodeling of GAM phenotypes results from the alteration of tumoral cholesterol homeostasis via IDH mutation‐induced PERK activation. [Image: see text]

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