PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia (Adv. Sci. 20/2023)

Tumor Microenvironment Cholesterol is the essential structural and functional component for glioma cells to maintain their biological aggressiveness. In article number 2205949, Yulong He, Yonggao Mou, Ningning Li, and co‐workers identify that excessive cholesterol excreted from IDH‐mutant glioma cel...

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Autores principales: Wang, Tao, Zhou, Yunxia, Fan, Yunping, Duan, Hao, Guo, Xiaoyu, Chang, Jinlong, Jiang, Youheng, Li, Changxue, Fu, Zhang, Gao, Yunfei, Guo, Xiaoran, Sidlauskas, Kastytis, He, Zhenqiang, Da Costa, Clive, Sheng, Xia, Wu, Dinglan, Yuan, Jinqiu, Li, Huiliang, He, Yulong, Mou, Yonggao, Li, Ningning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Inside Front Cover
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369288/
http://dx.doi.org/10.1002/advs.202370127
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author Wang, Tao
Zhou, Yunxia
Fan, Yunping
Duan, Hao
Guo, Xiaoyu
Chang, Jinlong
Jiang, Youheng
Li, Changxue
Fu, Zhang
Gao, Yunfei
Guo, Xiaoran
Sidlauskas, Kastytis
He, Zhenqiang
Da Costa, Clive
Sheng, Xia
Wu, Dinglan
Yuan, Jinqiu
Li, Huiliang
He, Yulong
Mou, Yonggao
Li, Ningning
author_facet Wang, Tao
Zhou, Yunxia
Fan, Yunping
Duan, Hao
Guo, Xiaoyu
Chang, Jinlong
Jiang, Youheng
Li, Changxue
Fu, Zhang
Gao, Yunfei
Guo, Xiaoran
Sidlauskas, Kastytis
He, Zhenqiang
Da Costa, Clive
Sheng, Xia
Wu, Dinglan
Yuan, Jinqiu
Li, Huiliang
He, Yulong
Mou, Yonggao
Li, Ningning
author_sort Wang, Tao
collection PubMed
description Tumor Microenvironment Cholesterol is the essential structural and functional component for glioma cells to maintain their biological aggressiveness. In article number 2205949, Yulong He, Yonggao Mou, Ningning Li, and co‐workers identify that excessive cholesterol excreted from IDH‐mutant glioma cells, as a metabolic messenger, determines M1‐like polarization of glioma‐associated microglia/macrophage (GAMs). This study reveals that the remodeling of GAM phenotypes results from the alteration of tumoral cholesterol homeostasis via IDH mutation‐induced PERK activation. [Image: see text]
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spelling pubmed-103692882023-07-27 PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia (Adv. Sci. 20/2023) Wang, Tao Zhou, Yunxia Fan, Yunping Duan, Hao Guo, Xiaoyu Chang, Jinlong Jiang, Youheng Li, Changxue Fu, Zhang Gao, Yunfei Guo, Xiaoran Sidlauskas, Kastytis He, Zhenqiang Da Costa, Clive Sheng, Xia Wu, Dinglan Yuan, Jinqiu Li, Huiliang He, Yulong Mou, Yonggao Li, Ningning Adv Sci (Weinh) Inside Front Cover Tumor Microenvironment Cholesterol is the essential structural and functional component for glioma cells to maintain their biological aggressiveness. In article number 2205949, Yulong He, Yonggao Mou, Ningning Li, and co‐workers identify that excessive cholesterol excreted from IDH‐mutant glioma cells, as a metabolic messenger, determines M1‐like polarization of glioma‐associated microglia/macrophage (GAMs). This study reveals that the remodeling of GAM phenotypes results from the alteration of tumoral cholesterol homeostasis via IDH mutation‐induced PERK activation. [Image: see text] John Wiley and Sons Inc. 2023-07-26 /pmc/articles/PMC10369288/ http://dx.doi.org/10.1002/advs.202370127 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Inside Front Cover
Wang, Tao
Zhou, Yunxia
Fan, Yunping
Duan, Hao
Guo, Xiaoyu
Chang, Jinlong
Jiang, Youheng
Li, Changxue
Fu, Zhang
Gao, Yunfei
Guo, Xiaoran
Sidlauskas, Kastytis
He, Zhenqiang
Da Costa, Clive
Sheng, Xia
Wu, Dinglan
Yuan, Jinqiu
Li, Huiliang
He, Yulong
Mou, Yonggao
Li, Ningning
PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia (Adv. Sci. 20/2023)
title PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia (Adv. Sci. 20/2023)
title_full PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia (Adv. Sci. 20/2023)
title_fullStr PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia (Adv. Sci. 20/2023)
title_full_unstemmed PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia (Adv. Sci. 20/2023)
title_short PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia (Adv. Sci. 20/2023)
title_sort perk‐mediated cholesterol excretion from idh mutant glioma determines anti‐tumoral polarization of microglia (adv. sci. 20/2023)
topic Inside Front Cover
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369288/
http://dx.doi.org/10.1002/advs.202370127
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