Cargando…
The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience
AIM OF THE STUDY: The treatment of autoimmune hepatitis (AIH) is based on steroids and azathioprine (AZA). AZA is a pro-drug which is converted among others into 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP). The aim of the study was to determine the relationship between the AZA active met...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369651/ https://www.ncbi.nlm.nih.gov/pubmed/37502437 http://dx.doi.org/10.5114/ceh.2023.127442 |
_version_ | 1785077803211816960 |
---|---|
author | Kaps-Kopiec, Dominika Czajkowska, Agnieszka Górska, Marta Woźniak, Małgorzata Jarzębicka, Dorota Cielecka-Kuszyk, Joanna Czubkowski, Piotr Pawłowska, Joanna |
author_facet | Kaps-Kopiec, Dominika Czajkowska, Agnieszka Górska, Marta Woźniak, Małgorzata Jarzębicka, Dorota Cielecka-Kuszyk, Joanna Czubkowski, Piotr Pawłowska, Joanna |
author_sort | Kaps-Kopiec, Dominika |
collection | PubMed |
description | AIM OF THE STUDY: The treatment of autoimmune hepatitis (AIH) is based on steroids and azathioprine (AZA). AZA is a pro-drug which is converted among others into 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP). The aim of the study was to determine the relationship between the AZA active metabolite 6-TG and both the biochemical and histological remission outcomes. MATERIAL AND METHODS: The authors conducted a retrospective analysis of a single chart review. The sample size consisted of 44 pediatric patients with AIH. Biochemical remission was defined as an alanine aminotransferase (ALT) level below 40 U/l and histological remission was defined as a situation when the control biopsy revealed inflammation grade G1 (or lower) in the Batts-Ludwig score. Statistical analysis was applied to assess the difference in remission outcomes in patients with different levels of 6-TG. RESULTS: In the benchmark variant of our statistical analysis, we found that the correlation between 6-TG and ALT in the sample was not statistically significant. Moreover, the difference between the mean levels of ALT in the populations in and without remission was not statistically significant (the p-value of the t-test was 0.16). CONCLUSIONS: Our results tend to support the claim that there is no statistically significant relationship between 6-TG concentration and remission (both biochemical and histological) in pediatric patients with AIH. |
format | Online Article Text |
id | pubmed-10369651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-103696512023-07-27 The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience Kaps-Kopiec, Dominika Czajkowska, Agnieszka Górska, Marta Woźniak, Małgorzata Jarzębicka, Dorota Cielecka-Kuszyk, Joanna Czubkowski, Piotr Pawłowska, Joanna Clin Exp Hepatol Original Paper AIM OF THE STUDY: The treatment of autoimmune hepatitis (AIH) is based on steroids and azathioprine (AZA). AZA is a pro-drug which is converted among others into 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP). The aim of the study was to determine the relationship between the AZA active metabolite 6-TG and both the biochemical and histological remission outcomes. MATERIAL AND METHODS: The authors conducted a retrospective analysis of a single chart review. The sample size consisted of 44 pediatric patients with AIH. Biochemical remission was defined as an alanine aminotransferase (ALT) level below 40 U/l and histological remission was defined as a situation when the control biopsy revealed inflammation grade G1 (or lower) in the Batts-Ludwig score. Statistical analysis was applied to assess the difference in remission outcomes in patients with different levels of 6-TG. RESULTS: In the benchmark variant of our statistical analysis, we found that the correlation between 6-TG and ALT in the sample was not statistically significant. Moreover, the difference between the mean levels of ALT in the populations in and without remission was not statistically significant (the p-value of the t-test was 0.16). CONCLUSIONS: Our results tend to support the claim that there is no statistically significant relationship between 6-TG concentration and remission (both biochemical and histological) in pediatric patients with AIH. Termedia Publishing House 2023-06-26 2023-06 /pmc/articles/PMC10369651/ /pubmed/37502437 http://dx.doi.org/10.5114/ceh.2023.127442 Text en Copyright © 2023 Clinical and Experimental Hepatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Original Paper Kaps-Kopiec, Dominika Czajkowska, Agnieszka Górska, Marta Woźniak, Małgorzata Jarzębicka, Dorota Cielecka-Kuszyk, Joanna Czubkowski, Piotr Pawłowska, Joanna The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience |
title | The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience |
title_full | The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience |
title_fullStr | The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience |
title_full_unstemmed | The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience |
title_short | The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience |
title_sort | relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. single center experience |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369651/ https://www.ncbi.nlm.nih.gov/pubmed/37502437 http://dx.doi.org/10.5114/ceh.2023.127442 |
work_keys_str_mv | AT kapskopiecdominika therelationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT czajkowskaagnieszka therelationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT gorskamarta therelationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT wozniakmałgorzata therelationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT jarzebickadorota therelationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT cieleckakuszykjoanna therelationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT czubkowskipiotr therelationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT pawłowskajoanna therelationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT kapskopiecdominika relationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT czajkowskaagnieszka relationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT gorskamarta relationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT wozniakmałgorzata relationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT jarzebickadorota relationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT cieleckakuszykjoanna relationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT czubkowskipiotr relationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience AT pawłowskajoanna relationshipbetween6thioguaninelevelsandremissionoutcomesinchildrenwithautoimmunehepatitissinglecenterexperience |