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The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience

AIM OF THE STUDY: The treatment of autoimmune hepatitis (AIH) is based on steroids and azathioprine (AZA). AZA is a pro-drug which is converted among others into 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP). The aim of the study was to determine the relationship between the AZA active met...

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Autores principales: Kaps-Kopiec, Dominika, Czajkowska, Agnieszka, Górska, Marta, Woźniak, Małgorzata, Jarzębicka, Dorota, Cielecka-Kuszyk, Joanna, Czubkowski, Piotr, Pawłowska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369651/
https://www.ncbi.nlm.nih.gov/pubmed/37502437
http://dx.doi.org/10.5114/ceh.2023.127442
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author Kaps-Kopiec, Dominika
Czajkowska, Agnieszka
Górska, Marta
Woźniak, Małgorzata
Jarzębicka, Dorota
Cielecka-Kuszyk, Joanna
Czubkowski, Piotr
Pawłowska, Joanna
author_facet Kaps-Kopiec, Dominika
Czajkowska, Agnieszka
Górska, Marta
Woźniak, Małgorzata
Jarzębicka, Dorota
Cielecka-Kuszyk, Joanna
Czubkowski, Piotr
Pawłowska, Joanna
author_sort Kaps-Kopiec, Dominika
collection PubMed
description AIM OF THE STUDY: The treatment of autoimmune hepatitis (AIH) is based on steroids and azathioprine (AZA). AZA is a pro-drug which is converted among others into 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP). The aim of the study was to determine the relationship between the AZA active metabolite 6-TG and both the biochemical and histological remission outcomes. MATERIAL AND METHODS: The authors conducted a retrospective analysis of a single chart review. The sample size consisted of 44 pediatric patients with AIH. Biochemical remission was defined as an alanine aminotransferase (ALT) level below 40 U/l and histological remission was defined as a situation when the control biopsy revealed inflammation grade G1 (or lower) in the Batts-Ludwig score. Statistical analysis was applied to assess the difference in remission outcomes in patients with different levels of 6-TG. RESULTS: In the benchmark variant of our statistical analysis, we found that the correlation between 6-TG and ALT in the sample was not statistically significant. Moreover, the difference between the mean levels of ALT in the populations in and without remission was not statistically significant (the p-value of the t-test was 0.16). CONCLUSIONS: Our results tend to support the claim that there is no statistically significant relationship between 6-TG concentration and remission (both biochemical and histological) in pediatric patients with AIH.
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spelling pubmed-103696512023-07-27 The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience Kaps-Kopiec, Dominika Czajkowska, Agnieszka Górska, Marta Woźniak, Małgorzata Jarzębicka, Dorota Cielecka-Kuszyk, Joanna Czubkowski, Piotr Pawłowska, Joanna Clin Exp Hepatol Original Paper AIM OF THE STUDY: The treatment of autoimmune hepatitis (AIH) is based on steroids and azathioprine (AZA). AZA is a pro-drug which is converted among others into 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP). The aim of the study was to determine the relationship between the AZA active metabolite 6-TG and both the biochemical and histological remission outcomes. MATERIAL AND METHODS: The authors conducted a retrospective analysis of a single chart review. The sample size consisted of 44 pediatric patients with AIH. Biochemical remission was defined as an alanine aminotransferase (ALT) level below 40 U/l and histological remission was defined as a situation when the control biopsy revealed inflammation grade G1 (or lower) in the Batts-Ludwig score. Statistical analysis was applied to assess the difference in remission outcomes in patients with different levels of 6-TG. RESULTS: In the benchmark variant of our statistical analysis, we found that the correlation between 6-TG and ALT in the sample was not statistically significant. Moreover, the difference between the mean levels of ALT in the populations in and without remission was not statistically significant (the p-value of the t-test was 0.16). CONCLUSIONS: Our results tend to support the claim that there is no statistically significant relationship between 6-TG concentration and remission (both biochemical and histological) in pediatric patients with AIH. Termedia Publishing House 2023-06-26 2023-06 /pmc/articles/PMC10369651/ /pubmed/37502437 http://dx.doi.org/10.5114/ceh.2023.127442 Text en Copyright © 2023 Clinical and Experimental Hepatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Original Paper
Kaps-Kopiec, Dominika
Czajkowska, Agnieszka
Górska, Marta
Woźniak, Małgorzata
Jarzębicka, Dorota
Cielecka-Kuszyk, Joanna
Czubkowski, Piotr
Pawłowska, Joanna
The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience
title The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience
title_full The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience
title_fullStr The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience
title_full_unstemmed The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience
title_short The relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. Single center experience
title_sort relationship between 6-thioguanine levels and remission outcomes in children with autoimmune hepatitis. single center experience
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369651/
https://www.ncbi.nlm.nih.gov/pubmed/37502437
http://dx.doi.org/10.5114/ceh.2023.127442
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