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Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease
In addition to having inflammation in the liver, overweight people also have changes in the composition of their immune systems and subsets of their immune systems. There are several genes involved in liver metabolism that have been implicated in nonalcoholic fatty liver disease (NAFLD), a liver dis...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Termedia Publishing House
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369655/ https://www.ncbi.nlm.nih.gov/pubmed/37502439 http://dx.doi.org/10.5114/ceh.2023.128633 |
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author | Sokouti, Babak |
author_facet | Sokouti, Babak |
author_sort | Sokouti, Babak |
collection | PubMed |
description | In addition to having inflammation in the liver, overweight people also have changes in the composition of their immune systems and subsets of their immune systems. There are several genes involved in liver metabolism that have been implicated in nonalcoholic fatty liver disease (NAFLD), a liver disease associated with obesity, which is caused by high triglycerides and liver transaminases. NAFLD, a global liver disease, may differ in gene expression depending on where a person lives. In some alleles, the risk factors were independent. Finally, the researchers identified many genetic variations connected to fatty liver disease in those who did not drink alcohol regularly. These variants were located in genes involved in RNA metabolism, protein catabolism, and energy metabolism. |
format | Online Article Text |
id | pubmed-10369655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-103696552023-07-27 Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease Sokouti, Babak Clin Exp Hepatol Review Paper In addition to having inflammation in the liver, overweight people also have changes in the composition of their immune systems and subsets of their immune systems. There are several genes involved in liver metabolism that have been implicated in nonalcoholic fatty liver disease (NAFLD), a liver disease associated with obesity, which is caused by high triglycerides and liver transaminases. NAFLD, a global liver disease, may differ in gene expression depending on where a person lives. In some alleles, the risk factors were independent. Finally, the researchers identified many genetic variations connected to fatty liver disease in those who did not drink alcohol regularly. These variants were located in genes involved in RNA metabolism, protein catabolism, and energy metabolism. Termedia Publishing House 2023-06-21 2023-06 /pmc/articles/PMC10369655/ /pubmed/37502439 http://dx.doi.org/10.5114/ceh.2023.128633 Text en Copyright © 2023 Clinical and Experimental Hepatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Review Paper Sokouti, Babak Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease |
title | Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease |
title_full | Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease |
title_fullStr | Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease |
title_full_unstemmed | Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease |
title_short | Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease |
title_sort | significant roles of potential genes and their mutations in nonalcoholic fatty liver disease |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369655/ https://www.ncbi.nlm.nih.gov/pubmed/37502439 http://dx.doi.org/10.5114/ceh.2023.128633 |
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