Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice

BACKGROUND: Alzheimer’s disease (AD) is the leading cause of dementia in the world. The pathology of AD is affiliated with the elevation of both tau (τ) and β-amyloid (Aβ) pathologies. Yet, the direct link between natural τ expression on glia cell activity and Aβ remains unclear. While experiments i...

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Detalles Bibliográficos
Autores principales: Farfara, Dorit, Sooliman, Meital, Avrahami, Limor, Royal, Tabitha Grace, Amram, Shoshik, Rozenstein-Tsalkovich, Lea, Trudler, Dorit, Blanga-Kanfi, Shani, Eldar-Finkelman, Hagit, Pahnke, Jens, Rosenmann, Hanna, Frenkel, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369740/
https://www.ncbi.nlm.nih.gov/pubmed/37496076
http://dx.doi.org/10.1186/s12974-023-02823-9

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