Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress

Amyotrophic lateral sclerosis (ALS) is a disease that affects motor neurons and has a poor prognosis. We focused on TAR DNA-binding protein 43 kDa (TDP-43), which is a common component of neuronal inclusions in many ALS patients. To analyze the contribution of TDP-43 mutations to ALS in human cells,...

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Detalles Bibliográficos
Autores principales: Onda-Ohto, Asako, Hasegawa-Ogawa, Minami, Matsuno, Hiromasa, Shiraishi, Tomotaka, Bono, Keiko, Hiraki, Hiromi, Kanegae, Yumi, Iguchi, Yasuyuki, Okano, Hirotaka James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369818/
https://www.ncbi.nlm.nih.gov/pubmed/37496071
http://dx.doi.org/10.1186/s13041-023-01050-w

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