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A discrete‐time survival model for porcine epidemic diarrhoea virus

Since the arrival of porcine epidemic diarrhea virus (PEDV) in the United States in 2013, elimination and control programmes have had partial success. The dynamics of its spread are hard to quantify, though previous work has shown that local transmission and the transfer of pigs within production sy...

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Autores principales: Trostle, Parker, Corzo, Cesar A., Reich, Brian J., Machado, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369857/
https://www.ncbi.nlm.nih.gov/pubmed/36217910
http://dx.doi.org/10.1111/tbed.14739
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author Trostle, Parker
Corzo, Cesar A.
Reich, Brian J.
Machado, Gustavo
author_facet Trostle, Parker
Corzo, Cesar A.
Reich, Brian J.
Machado, Gustavo
author_sort Trostle, Parker
collection PubMed
description Since the arrival of porcine epidemic diarrhea virus (PEDV) in the United States in 2013, elimination and control programmes have had partial success. The dynamics of its spread are hard to quantify, though previous work has shown that local transmission and the transfer of pigs within production systems are most associated with the spread of PEDV. Our work relies on the history of PEDV infections in a region of the southeastern United States. This infection data is complemented by farm‐level features and extensive industry data on the movement of both pigs and vehicles. We implement a discrete‐time survival model and evaluate different approaches to modelling the local‐transmission and network effects. We find strong evidence in that the local‐transmission and pig‐movement effects are associated with the spread of PEDV, even while controlling for seasonality, farm‐level features and the possible spread of disease by vehicles. Our fully Bayesian model permits full uncertainty quantification of these effects. Our farm‐level out‐of‐sample predictions have a receiver‐operating characteristic area under the curve (AUC) of 0.779 and a precision‐recall AUC of 0.097. The quantification of these effects in a comprehensive model allows stakeholders to make more informed decisions about disease prevention efforts.
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spelling pubmed-103698572023-07-27 A discrete‐time survival model for porcine epidemic diarrhoea virus Trostle, Parker Corzo, Cesar A. Reich, Brian J. Machado, Gustavo Transbound Emerg Dis Original Articles Since the arrival of porcine epidemic diarrhea virus (PEDV) in the United States in 2013, elimination and control programmes have had partial success. The dynamics of its spread are hard to quantify, though previous work has shown that local transmission and the transfer of pigs within production systems are most associated with the spread of PEDV. Our work relies on the history of PEDV infections in a region of the southeastern United States. This infection data is complemented by farm‐level features and extensive industry data on the movement of both pigs and vehicles. We implement a discrete‐time survival model and evaluate different approaches to modelling the local‐transmission and network effects. We find strong evidence in that the local‐transmission and pig‐movement effects are associated with the spread of PEDV, even while controlling for seasonality, farm‐level features and the possible spread of disease by vehicles. Our fully Bayesian model permits full uncertainty quantification of these effects. Our farm‐level out‐of‐sample predictions have a receiver‐operating characteristic area under the curve (AUC) of 0.779 and a precision‐recall AUC of 0.097. The quantification of these effects in a comprehensive model allows stakeholders to make more informed decisions about disease prevention efforts. John Wiley and Sons Inc. 2022-10-29 2022-11 /pmc/articles/PMC10369857/ /pubmed/36217910 http://dx.doi.org/10.1111/tbed.14739 Text en © 2022 The Authors. Transboundary and Emerging Diseases published by Wiley‐VCH GmbH. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Trostle, Parker
Corzo, Cesar A.
Reich, Brian J.
Machado, Gustavo
A discrete‐time survival model for porcine epidemic diarrhoea virus
title A discrete‐time survival model for porcine epidemic diarrhoea virus
title_full A discrete‐time survival model for porcine epidemic diarrhoea virus
title_fullStr A discrete‐time survival model for porcine epidemic diarrhoea virus
title_full_unstemmed A discrete‐time survival model for porcine epidemic diarrhoea virus
title_short A discrete‐time survival model for porcine epidemic diarrhoea virus
title_sort discrete‐time survival model for porcine epidemic diarrhoea virus
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369857/
https://www.ncbi.nlm.nih.gov/pubmed/36217910
http://dx.doi.org/10.1111/tbed.14739
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