Native dynamics and allosteric responses in PTP1B probed by high-resolution HDX-MS

Protein tyrosine phosphatase 1B (PTP1B) is a validated therapeutic target for obesity, diabetes, and certain types of cancer. In particular, allosteric inhibitors hold potential for therapeutic use, but an incomplete understanding of conformational dynamics and allostery in this protein has hindered...

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Detalles Bibliográficos
Autores principales: Woods, Virgil A., Abzalimov, Rinat R., Keedy, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369962/
https://www.ncbi.nlm.nih.gov/pubmed/37503000
http://dx.doi.org/10.1101/2023.07.12.548582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369962/
https://www.ncbi.nlm.nih.gov/pubmed/37503000
http://dx.doi.org/10.1101/2023.07.12.548582

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