Ebola Virus VP35 Interacts Non-Covalently with Ubiquitin Chains to Promote Viral Replication Creating New Therapeutic Opportunities

Ebolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase complex, which includes the co-factor and Interferon antagonist VP35. We previously showed that the covalent ubiquitination...

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Detalles Bibliográficos
Autores principales: Rodríguez-Salazar, Carlos A., van Tol, Sarah, Mailhot, Olivier, Galdino, Gabriel, Teruel, Natalia, Zhang, Lihong, Warren, Abbey N., González-Orozco, María, Freiberg, Alexander N., Najmanovich, Rafael J., Giraldo, María I., Rajsbaum, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10369991/
https://www.ncbi.nlm.nih.gov/pubmed/37503276
http://dx.doi.org/10.1101/2023.07.14.549057

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