High throughput PRIME editing screens identify functional DNA variants in the human genome

Despite tremendous progress in detecting DNA variants associated with human disease, interpreting their functional impact in a high-throughput and base-pair resolution manner remains challenging. Here, we develop a novel pooled prime editing screen method, PRIME, which can be applied to characterize...

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Detalles Bibliográficos
Autores principales: Ren, Xingjie, Yang, Han, Nierenberg, Jovia L., Sun, Yifan, Chen, Jiawen, Beaman, Cooper, Pham, Thu, Nobuhara, Mai, Takagi, Maya Asami, Narayan, Vivek, Li, Yun, Ziv, Elad, Shen, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370011/
https://www.ncbi.nlm.nih.gov/pubmed/37502948
http://dx.doi.org/10.1101/2023.07.12.548736

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