Mechanism of target site selection by type V-K CRISPR-associated transposases

Unlike canonical CRISPR-Cas systems that rely on RNA-guided nucleases for target cleavage, CRISPR-associated transposases (CASTs) repurpose nuclease-deficient CRISPR effectors to facilitate RNA-guided transposition of large genetic payloads. Type V-K CASTs offer several potential upsides for genome...

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Detalles Bibliográficos
Autores principales: George, Jerrin Thomas, Acree, Christopher, Park, Jung-Un, Kong, Muwen, Wiegand, Tanner, Pignot, Yanis Luca, Kellogg, Elizabeth H., Greene, Eric C., Sternberg, Samuel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370016/
https://www.ncbi.nlm.nih.gov/pubmed/37503092
http://dx.doi.org/10.1101/2023.07.14.548620

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