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An epigenome-wide association study of child appetitive traits and DNA methylation

Childhood appetitive traits are consistently associated with obesity risk, and yet their etiology is poorly understood. Appetitive traits are complex phenotypes which are hypothesized to be influenced by both genetic and environmental factors, as well as their interactions. Early-life epigenetic pro...

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Autores principales: Harris, Holly A., Friedman, Chloe, Starling, Anne P., Dabelea, Dana, Johnson, Susan L., Fuemmeler, Bernard F., Jima, Dereje, Murphy, Susan K., Hoyo, Cathrine, Jansen, Pauline W., Felix, Janine F., Mulder, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370073/
https://www.ncbi.nlm.nih.gov/pubmed/37503194
http://dx.doi.org/10.1101/2023.07.17.549289
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author Harris, Holly A.
Friedman, Chloe
Starling, Anne P.
Dabelea, Dana
Johnson, Susan L.
Fuemmeler, Bernard F.
Jima, Dereje
Murphy, Susan K.
Hoyo, Cathrine
Jansen, Pauline W.
Felix, Janine F.
Mulder, Rosa
author_facet Harris, Holly A.
Friedman, Chloe
Starling, Anne P.
Dabelea, Dana
Johnson, Susan L.
Fuemmeler, Bernard F.
Jima, Dereje
Murphy, Susan K.
Hoyo, Cathrine
Jansen, Pauline W.
Felix, Janine F.
Mulder, Rosa
author_sort Harris, Holly A.
collection PubMed
description Childhood appetitive traits are consistently associated with obesity risk, and yet their etiology is poorly understood. Appetitive traits are complex phenotypes which are hypothesized to be influenced by both genetic and environmental factors, as well as their interactions. Early-life epigenetic processes, such as DNA methylation (DNAm), may be involved in the developmental programming of appetite regulation in childhood. In the current study, we meta-analyzed epigenome-wide association studies (EWASs) of cord blood DNAm and early-childhood appetitive traits. Data were from two independent cohorts: the Generation R Study (n=1,086, Rotterdam, the Netherlands) and the Healthy Start study (n=236, Colorado, USA). DNAm at autosomal methylation sites in cord blood was measured using the Illumina Infinium HumanMethylation450 BeadChip. Parents reported on their child’s food responsiveness, emotional undereating, satiety responsiveness and food fussiness using the Children’s Eating Behaviour Questionnaire at age 4–5 years. Multiple regression models were used to examine the association of DNAm (predictor) at the individual site- and regional-level (using DMRff) with each appetitive trait (outcome), adjusting for covariates. Bonferroni-correction was applied to adjust for multiple testing. There were no associations of DNAm and any appetitive trait at the individual site-level. However, at the regional level, we identified 45 associations of DNAm with food responsiveness, 7 associations of DNAm with emotional undereating, 13 associations of DNAm with satiety responsiveness, and 9 associations of DNAm with food fussiness. This study shows that DNAm in the newborn may partially explain variation in appetitive traits expressed in early childhood and provides preliminary support for early programming of child appetitive traits through DNAm. Investigating differential DNAm associated with appetitive traits could be an important first step in identifying biological pathways underlying the development of these behaviors.
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spelling pubmed-103700732023-07-27 An epigenome-wide association study of child appetitive traits and DNA methylation Harris, Holly A. Friedman, Chloe Starling, Anne P. Dabelea, Dana Johnson, Susan L. Fuemmeler, Bernard F. Jima, Dereje Murphy, Susan K. Hoyo, Cathrine Jansen, Pauline W. Felix, Janine F. Mulder, Rosa bioRxiv Article Childhood appetitive traits are consistently associated with obesity risk, and yet their etiology is poorly understood. Appetitive traits are complex phenotypes which are hypothesized to be influenced by both genetic and environmental factors, as well as their interactions. Early-life epigenetic processes, such as DNA methylation (DNAm), may be involved in the developmental programming of appetite regulation in childhood. In the current study, we meta-analyzed epigenome-wide association studies (EWASs) of cord blood DNAm and early-childhood appetitive traits. Data were from two independent cohorts: the Generation R Study (n=1,086, Rotterdam, the Netherlands) and the Healthy Start study (n=236, Colorado, USA). DNAm at autosomal methylation sites in cord blood was measured using the Illumina Infinium HumanMethylation450 BeadChip. Parents reported on their child’s food responsiveness, emotional undereating, satiety responsiveness and food fussiness using the Children’s Eating Behaviour Questionnaire at age 4–5 years. Multiple regression models were used to examine the association of DNAm (predictor) at the individual site- and regional-level (using DMRff) with each appetitive trait (outcome), adjusting for covariates. Bonferroni-correction was applied to adjust for multiple testing. There were no associations of DNAm and any appetitive trait at the individual site-level. However, at the regional level, we identified 45 associations of DNAm with food responsiveness, 7 associations of DNAm with emotional undereating, 13 associations of DNAm with satiety responsiveness, and 9 associations of DNAm with food fussiness. This study shows that DNAm in the newborn may partially explain variation in appetitive traits expressed in early childhood and provides preliminary support for early programming of child appetitive traits through DNAm. Investigating differential DNAm associated with appetitive traits could be an important first step in identifying biological pathways underlying the development of these behaviors. Cold Spring Harbor Laboratory 2023-07-18 /pmc/articles/PMC10370073/ /pubmed/37503194 http://dx.doi.org/10.1101/2023.07.17.549289 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Harris, Holly A.
Friedman, Chloe
Starling, Anne P.
Dabelea, Dana
Johnson, Susan L.
Fuemmeler, Bernard F.
Jima, Dereje
Murphy, Susan K.
Hoyo, Cathrine
Jansen, Pauline W.
Felix, Janine F.
Mulder, Rosa
An epigenome-wide association study of child appetitive traits and DNA methylation
title An epigenome-wide association study of child appetitive traits and DNA methylation
title_full An epigenome-wide association study of child appetitive traits and DNA methylation
title_fullStr An epigenome-wide association study of child appetitive traits and DNA methylation
title_full_unstemmed An epigenome-wide association study of child appetitive traits and DNA methylation
title_short An epigenome-wide association study of child appetitive traits and DNA methylation
title_sort epigenome-wide association study of child appetitive traits and dna methylation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370073/
https://www.ncbi.nlm.nih.gov/pubmed/37503194
http://dx.doi.org/10.1101/2023.07.17.549289
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