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Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

Nonstructural protein 5 (Nsp5) is the main protease of SARS-CoV-2 that cleaves viral polyproteins into individual polypeptides necessary for viral replication. Here, we show that Nsp5 binds and cleaves human tRNA methyltransferase 1 (TRMT1), a host enzyme required for a prevalent post-transcriptiona...

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Detalles Bibliográficos
Autores principales:	Zhang, Kejia, Eldin, Patrick, Ciesla, Jessica H., Briant, Laurence, Lentini, Jenna M., Ramos, Jillian, Cobb, Justin, Munger, Joshua, Fu, Dragony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370084/ https://www.ncbi.nlm.nih.gov/pubmed/37502865 http://dx.doi.org/10.1101/2023.02.10.527147

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