R-loop landscapes in the developing human brain are linked to neural differentiation and cell-type specific transcription

Here, we construct genome-scale maps for R-loops, three-stranded nucleic acid structures comprised of a DNA/RNA hybrid and a displaced single strand of DNA, in the proliferative and differentiated zones of the human prenatal brain. We show that R-loops are abundant in the progenitor-rich germinal ma...

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Detalles Bibliográficos
Autores principales: LaMarca, Elizabeth A., Saito, Atsushi, Plaza-Jennings, Amara, Espeso-Gil, Sergio, Hellmich, Allyse, Fernando, Michael B., Javidfar, Behnam, Liao, Will, Estill, Molly, Townsley, Kayla, Florio, Anna, Ethridge, James E., Do, Catherine, Tycko, Benjamin, Shen, Li, Kamiya, Atsushi, Tsankova, Nadejda M., Brennand, Kristen J., Akbarian, Schahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370098/
https://www.ncbi.nlm.nih.gov/pubmed/37503149
http://dx.doi.org/10.1101/2023.07.18.549494

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