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Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years
Measures of intrinsic brain function at rest show promise as predictors of cognitive decline in humans, including EEG metrics such as individual alpha peak frequency (IAPF) and the aperiodic exponent, reflecting the strongest frequency of alpha oscillations and the relative balance of excitatory:inh...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370116/ https://www.ncbi.nlm.nih.gov/pubmed/37503078 http://dx.doi.org/10.1101/2023.07.17.549371 |
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author | Finley, Anna J. Angus, Douglas J. Knight, Erik van Reekum, Carien M. Lachman, Margie E. Davidson, Richard J. Schaefer, Stacey M. |
author_facet | Finley, Anna J. Angus, Douglas J. Knight, Erik van Reekum, Carien M. Lachman, Margie E. Davidson, Richard J. Schaefer, Stacey M. |
author_sort | Finley, Anna J. |
collection | PubMed |
description | Measures of intrinsic brain function at rest show promise as predictors of cognitive decline in humans, including EEG metrics such as individual alpha peak frequency (IAPF) and the aperiodic exponent, reflecting the strongest frequency of alpha oscillations and the relative balance of excitatory:inhibitory neural activity, respectively. Both IAPF and the aperiodic exponent decrease with age and have been associated with worse executive function and working memory. However, few studies have jointly examined their associations with cognitive function, and none have examined their association with longitudinal cognitive decline rather than cross-sectional impairment. In a preregistered secondary analysis of data from the longitudinal Midlife in the United States (MIDUS) study, we tested whether IAPF and aperiodic exponent measured at rest predict cognitive function (N = 234; age at EEG recording M = 54.86, SD = 10.76) over 10 years. The IAPF and the aperiodic exponent interacted to predict decline in overall cognitive ability, even after controlling for age, sex, education, and lag between data collection timepoints. Post-hoc tests showed that “mismatched” IAPF and aperiodic exponents (e.g., higher exponent with lower IAPF) predicted greater cognitive decline compared to “matching” IAPF and aperiodic exponents (e.g., higher exponent with higher IAPF; lower IAPF with lower aperiodic exponent). These effects were largely driven by measures of executive function. Our findings provide the first evidence that IAPF and the aperiodic exponent are joint predictors of cognitive decline from midlife into old age and thus may offer a useful clinical tool for predicting cognitive risk in aging. |
format | Online Article Text |
id | pubmed-10370116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-103701162023-07-27 Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years Finley, Anna J. Angus, Douglas J. Knight, Erik van Reekum, Carien M. Lachman, Margie E. Davidson, Richard J. Schaefer, Stacey M. bioRxiv Article Measures of intrinsic brain function at rest show promise as predictors of cognitive decline in humans, including EEG metrics such as individual alpha peak frequency (IAPF) and the aperiodic exponent, reflecting the strongest frequency of alpha oscillations and the relative balance of excitatory:inhibitory neural activity, respectively. Both IAPF and the aperiodic exponent decrease with age and have been associated with worse executive function and working memory. However, few studies have jointly examined their associations with cognitive function, and none have examined their association with longitudinal cognitive decline rather than cross-sectional impairment. In a preregistered secondary analysis of data from the longitudinal Midlife in the United States (MIDUS) study, we tested whether IAPF and aperiodic exponent measured at rest predict cognitive function (N = 234; age at EEG recording M = 54.86, SD = 10.76) over 10 years. The IAPF and the aperiodic exponent interacted to predict decline in overall cognitive ability, even after controlling for age, sex, education, and lag between data collection timepoints. Post-hoc tests showed that “mismatched” IAPF and aperiodic exponents (e.g., higher exponent with lower IAPF) predicted greater cognitive decline compared to “matching” IAPF and aperiodic exponents (e.g., higher exponent with higher IAPF; lower IAPF with lower aperiodic exponent). These effects were largely driven by measures of executive function. Our findings provide the first evidence that IAPF and the aperiodic exponent are joint predictors of cognitive decline from midlife into old age and thus may offer a useful clinical tool for predicting cognitive risk in aging. Cold Spring Harbor Laboratory 2023-07-19 /pmc/articles/PMC10370116/ /pubmed/37503078 http://dx.doi.org/10.1101/2023.07.17.549371 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Finley, Anna J. Angus, Douglas J. Knight, Erik van Reekum, Carien M. Lachman, Margie E. Davidson, Richard J. Schaefer, Stacey M. Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years |
title | Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years |
title_full | Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years |
title_fullStr | Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years |
title_full_unstemmed | Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years |
title_short | Resting EEG Periodic and Aperiodic Components Predict Cognitive Decline Over 10 Years |
title_sort | resting eeg periodic and aperiodic components predict cognitive decline over 10 years |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370116/ https://www.ncbi.nlm.nih.gov/pubmed/37503078 http://dx.doi.org/10.1101/2023.07.17.549371 |
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