Five inhibitory receptors display distinct vesicular distributions in T cells

T cells can express multiple inhibitory receptors. Upon induction of T cell exhaustion in response to persistent antigen, prominently in the anti-tumor immune response, many are expressed simultaneously. Key inhibitory receptors are CTLA-4, PD-1, LAG3, TIM3 and TIGIT, as investigated here. These rec...

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Detalles Bibliográficos
Autores principales: Lu, Jiahe, Veler, Alisa, Simonetti, Boris, Raj, Timsse, Chou, Po Han, Cross, Stephen J., Phillips, Alexander M., Ruan, Xiongtao, Huynh, Lan, Dowsey, Andrew W., Ye, Dingwei, Murphy, Robert F., Verkade, Paul, Cullen, Peter J., Wülfing, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370166/
https://www.ncbi.nlm.nih.gov/pubmed/37503045
http://dx.doi.org/10.1101/2023.07.21.550019

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