Integrative determination of the atomic structure of mutant huntingtin exon 1 fibrils from Huntington’s disease

Neurodegeneration in Huntington’s disease (HD) is accompanied by the aggregation of fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular pathogenic role has been attributed to the aggregation-prone huntingtin exon 1 (HttEx1) fragment, whose polyglutamine (poly...

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Detalles Bibliográficos
Autores principales: Helabad, Mahdi Bagherpoor, Matlahov, Irina, Daldrop, Jan O., Jain, Greeshma, van der Wel, Patrick C.A., Miettinen, Markus S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370190/
https://www.ncbi.nlm.nih.gov/pubmed/37502911
http://dx.doi.org/10.1101/2023.07.21.549993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370190/
https://www.ncbi.nlm.nih.gov/pubmed/37502911
http://dx.doi.org/10.1101/2023.07.21.549993

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