Proteogenomic Approaches for the Identification of NF1/Neurofibromin-depleted Estrogen Receptor–positive Breast Cancers for Targeted Treatment

NF1 is a key tumor suppressor that represses both RAS and estrogen receptor-α (ER) signaling in breast cancer. Blocking both pathways by fulvestrant (F), a selective ER degrader, together with binimetinib (B), a MEK inhibitor, promotes tumor regression in NF1-depleted ER(+) models. We aimed to estab...

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Detalles Bibliográficos
Autores principales: Kim, Beom-Jun, Zheng, Ze-Yi, Lei, Jonathan T., Holt, Matthew V., Chen, Anran, Peng, Jianheng, Fandino, Diana, Singh, Purba, Kennedy, Hilda, Dou, Yongchao, Chica-Parrado, María del Rosario, Bikorimana, Emmanuel, Ye, Dan, Wang, Yunguan, Hanker, Ariella B., Mohamed, Nada, Hilsenbeck, Susan G., Lim, Bora, Asirvatham, Jaya Ruth, Sreekumar, Arun, Zhang, Bing, Miles, George, Anurag, Meenakshi, Ellis, Matthew J., Chang, Eric C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370361/
https://www.ncbi.nlm.nih.gov/pubmed/37501682
http://dx.doi.org/10.1158/2767-9764.CRC-23-0044

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