Cargando…

DEVELOPMENT OF A SELECTIVE CD16A-BASED NK CELL ENGAGER UTILIZING ANTIBODIES TARGETING A SINGLE AMINO ACID VARIATION

BACKGROUND AND SIGNIFICANCE: Natural killer (NK) cells play a vital role in the human innate immune system and are being explored as a promising approach for cancer immunotherapy. Of particular interest are NK cell engagers that can target and activate NK cells to attack cancer cells. In this study,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liao, Wuxiang, Tumanut, Christine, Li, Lin, Corper, Adam, Challa, Dilip, Chang, Alex, Begum, Hydari, Farokhi, Elinaz, Woods, Catherine, Fan, Xiaomin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Abstract
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370432/ http://dx.doi.org/10.1093/abt/tbad014.012

Ejemplares similares

A Potent SARS-CoV-2 Neutralizing Human Monoclonal Antibody That Reduces Viral Burden and Disease Severity in Syrian Hamsters
por: Fagre, Anna C., et al.
Publicado: (2020)

E-Cadherin Regulates Mitochondrial Membrane Potential in Cancer Cells
por: Begum, Hydari Masuma, et al.
Publicado: (2021)

Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells
por: Srpan, Katja, et al.
Publicado: (2018)

Bispecific killer cell engager with high affinity and specificity toward CD16a on NK cells for cancer immunotherapy
por: Nikkhoi, Shahryar Khoshtinat, et al.
Publicado: (2023)

Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123
por: Gauthier, Laurent, et al.
Publicado: (2023)

Ion Binding Properties of a Naturally Occurring Metalloantibody
por: Farokhi, Elinaz, et al.
Publicado: (2020)

The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice
por: Pandey, Rahul, et al.
Publicado: (2019)

Enhancing Neuroblastoma Immunotherapies by Engaging iNKT and NK Cells
por: McNerney, Kevin O., et al.
Publicado: (2020)

Engaging Cytotoxic T and NK Cells for Immunotherapy in Chronic Lymphocytic Leukemia
por: Hofland, Tom, et al.
Publicado: (2019)

Chronic NKG2D Engagement In Vivo Differentially Impacts NK Cell Responsiveness by Activating NK Receptors
por: Koch, Christine, et al.
Publicado: (2017)

NOTES ON THE SUBCUTANEOUS ABSORPTION AND THE QUANTITATIVE ESTIMATION OF CHOLESTEROL
por: Corper, Harry J.
Publicado: (1915)

CORRELATION OF THE HISTOLOGICAL AND CHEMICAL CHANGES IN THE SPLEEN DURING NECROSIS AND AUTOLYSIS
por: Corper, Harry J.
Publicado: (1912)

Bacillary and Tuberculin Allergy and their Relation to Specific Tuberculosis Immunity
por: Corper, H. J.
Publicado: (1943)

Exploring the Utility of NK Cells in COVID-19
por: Deng, Xuewen, et al.
Publicado: (2022)

High-throughput screening and validation of antibodies against synaptic proteins to explore opioid signaling dynamics
por: Lemos Duarte, Mariana, et al.
Publicado: (2021)

Continuous engagement of a self-specific activation receptor induces NK cell tolerance
por: Tripathy, Sandeep K., et al.
Publicado: (2008)

Generation of a symmetrical trispecific NK cell engager based on a two-in-one antibody
por: Harwardt, Julia, et al.
Publicado: (2023)

Reduction of the CD16(−)CD56(bright) NK Cell Subset Precedes NK Cell Dysfunction in Prostate Cancer
por: Koo, Kyo Chul, et al.
Publicado: (2013)

SAT-LB073 SJX-653, a Novel Selective NK3 Antagonist, Demonstrates Activity on Pharmacodynamic Markers of NK3 Target Engagement
por: Cormier, Jennifer, et al.
Publicado: (2019)

Balanced engagement of activating and inhibitory receptors mitigates human NK cell exhaustion
por: Myers, Jacob A., et al.
Publicado: (2022)

Report of a Novel Splicing Mutation in the MYO15A Gene in a Patient With Sensorineural Hearing Loss and Spectrum of the MYO15A Mutations
por: Akbariazar, Elinaz, et al.
Publicado: (2019)

An NK cell line (haNK) expressing high levels of granzyme and engineered to express the high affinity CD16 allele
por: Jochems, Caroline, et al.
Publicado: (2016)

A tri-specific killer engager against mesothelin targets NK cells towards lung cancer
por: Kennedy, Philippa R., et al.
Publicado: (2023)

Peptide-specific engagement of the activating NK cell receptor KIR2DS1
por: Chapel, Anaïs, et al.
Publicado: (2017)

Principles and current clinical landscape of NK cell engaging bispecific antibody against cancer
por: Huan, Tian, et al.
Publicado: (2023)

The Probable Mechanism of Streptomycin Action in Tuberculosis
por: Corper, H. J., et al.
Publicado: (1949)

Specific Tuberculosis Immunity During Infection
por: Corper, H. J., et al.
Publicado: (1944)

The Tubercle Bacillus and Fundamental Chemotherapeutic and Antibiotic Action
por: Corper, H. J., et al.
Publicado: (1946)

CLEC16A regulates splenocyte and NK cell function in part through MEK signaling
por: Pandey, Rahul, et al.
Publicado: (2018)

A novel GTPBP2 splicing mutation in two siblings affected with microcephaly, generalized muscular atrophy, and hypotrichosis
por: Abdi Rad, Isa, et al.
Publicado: (2020)

Bispecific NK-cell engager targeting BCMA elicits stronger antitumor effects and produces less proinflammatory cytokines than T-cell engager
por: Xiao, Xinghui, et al.
Publicado: (2023)

A HER2 Tri-Specific NK Cell Engager Mediates Efficient Targeting of Human Ovarian Cancer
por: Vallera, Daniel A., et al.
Publicado: (2021)

A vector-encoded bispecific killer engager to harness virus-activated NK cells as anti-tumor effectors
por: Floerchinger, Alessia, et al.
Publicado: (2023)

A NOVEL B7H3/NKP30 BISPECIFIC NK CELL ENGAGER FOR CANCER IMMUNOTHERAPY
por: Jiang, Xiaoling, et al.
Publicado: (2023)

CD56(neg)CD16(+) NK cells are activated mature NK cells with impaired effector function during HIV-1 infection
por: Milush, Jeffrey M, et al.
Publicado: (2013)

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
por: Niogret, Charlène, et al.
Publicado: (2019)

Engagement of lymphoma T cell receptors causes accelerated growth and the secretion of an NK cell-inhibitory factor
por: Dubois, Sigrid, et al.
Publicado: (2020)

Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer
por: Romee, Rizwan, et al.
Publicado: (2014)

Interleukin-16-producing NK cells and T-cells in the blood of tobacco smokers with and without COPD
por: Andersson, Anders, et al.
Publicado: (2016)

P16. Differential susceptibility of human and mouse NK cells to malignant cell-induced abnormalities in autologous combinations: a potential mechanism for the NK cell-based immunotherapy efficacy
por: Sconocchia, G, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_sgcfd6edp1su1dhgg9cmismk97