DISCOVERY OF NOVEL ANTI-SERUM ALBUMIN VHH AS A BUILDING BLOCK FOR PK PROLONGATION

BACKGROUND: The serum half-life of endogenous albumin is approximately 19 days in humans and 1.5-2.5 days in rodents. This extended half-life in vivo is primarily due to effective recycling upon internalization mediated by the neonatal Fc receptor (FcRn). Many protein therapeutics smaller than 60 kD...

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Detalles Bibliográficos
Autores principales: Chen, Yunying, Lin, Xin, Qin, Yi, Wu, Donghui, Gu, Jijie, Nie, Siwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370437/
http://dx.doi.org/10.1093/abt/tbad014.011

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