Moderate hypoxia induces metabolic divergence in circulating monocytes and tissue resident macrophages from Berkeley sickle cell anemia mice

INTRODUCTION: Human and murine sickle cell disease (SCD) associated pulmonary hypertension (PH) is defined by hemolysis, nitric oxide depletion, inflammation, and thrombosis. Further, hemoglobin (Hb), heme, and iron accumulation are consistently observed in pulmonary adventitial macrophages at autop...

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Detalles Bibliográficos
Autores principales: Lisk, Christina, Cendali, Francesca, Pak, David I., Swindle, Delaney, Hassell, Kathryn, Nuss, Rachelle, George, Gemlyn, Davizon-Castillo, Pavel, Buehler, Paul W., D’Alessandro, Angelo, Irwin, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370499/
https://www.ncbi.nlm.nih.gov/pubmed/37502360
http://dx.doi.org/10.3389/fmed.2023.1149005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370499/
https://www.ncbi.nlm.nih.gov/pubmed/37502360
http://dx.doi.org/10.3389/fmed.2023.1149005

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