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Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis
Circular RNAs (circRNAs) are a new acknowledged class of RNAs that has been shown to play a major role in several biological functions both in physiological and pathological conditions, operating as critical part of regulatory processes, like competing endogenous RNA (ceRNA) networks. The ceRNA hypo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370684/ https://www.ncbi.nlm.nih.gov/pubmed/37494404 http://dx.doi.org/10.1371/journal.pone.0289051 |
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author | Fiscon, Giulia Funari, Alessio Paci, Paola |
author_facet | Fiscon, Giulia Funari, Alessio Paci, Paola |
author_sort | Fiscon, Giulia |
collection | PubMed |
description | Circular RNAs (circRNAs) are a new acknowledged class of RNAs that has been shown to play a major role in several biological functions both in physiological and pathological conditions, operating as critical part of regulatory processes, like competing endogenous RNA (ceRNA) networks. The ceRNA hypothesis is a recently discovered molecular mechanism that adds a new key layer of post-transcriptional regulation, whereby various types of RNAs can reciprocally influence each other’s expression competing for binding the same pool of microRNAs, even affecting disease development. In this study, we build a network of circRNA-miRNA-mRNA interactions in human breast cancer, called CERNOMA, that is a bipartite graph with one class of nodes corresponding to differentially expressed miRNAs (DEMs) and the other one corresponding to differentially expressed circRNAs (DEC) and mRNAs (DEGs). A link between a DEC (or DEG) and DEM is placed if it is predicted to be a target of the DEM and shows an opposite expression level trend with respect to the DEM. Within the CERNOMA, we highlighted an interesting deregulated circRNA-miRNA-mRNA triplet, including the up-regulated hsa_circRNA_102908 (BRCA1 associated RING domain 1), the down-regulated miR‐410-3p, and the up-regulated ESM1, whose overexpression has been already shown to promote tumor dissemination and metastasis in breast cancer. |
format | Online Article Text |
id | pubmed-10370684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-103706842023-07-27 Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis Fiscon, Giulia Funari, Alessio Paci, Paola PLoS One Research Article Circular RNAs (circRNAs) are a new acknowledged class of RNAs that has been shown to play a major role in several biological functions both in physiological and pathological conditions, operating as critical part of regulatory processes, like competing endogenous RNA (ceRNA) networks. The ceRNA hypothesis is a recently discovered molecular mechanism that adds a new key layer of post-transcriptional regulation, whereby various types of RNAs can reciprocally influence each other’s expression competing for binding the same pool of microRNAs, even affecting disease development. In this study, we build a network of circRNA-miRNA-mRNA interactions in human breast cancer, called CERNOMA, that is a bipartite graph with one class of nodes corresponding to differentially expressed miRNAs (DEMs) and the other one corresponding to differentially expressed circRNAs (DEC) and mRNAs (DEGs). A link between a DEC (or DEG) and DEM is placed if it is predicted to be a target of the DEM and shows an opposite expression level trend with respect to the DEM. Within the CERNOMA, we highlighted an interesting deregulated circRNA-miRNA-mRNA triplet, including the up-regulated hsa_circRNA_102908 (BRCA1 associated RING domain 1), the down-regulated miR‐410-3p, and the up-regulated ESM1, whose overexpression has been already shown to promote tumor dissemination and metastasis in breast cancer. Public Library of Science 2023-07-26 /pmc/articles/PMC10370684/ /pubmed/37494404 http://dx.doi.org/10.1371/journal.pone.0289051 Text en © 2023 Fiscon et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Fiscon, Giulia Funari, Alessio Paci, Paola Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis |
title | Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis |
title_full | Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis |
title_fullStr | Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis |
title_full_unstemmed | Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis |
title_short | Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis |
title_sort | circular rna mediated gene regulation in human breast cancer: a bioinformatics analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370684/ https://www.ncbi.nlm.nih.gov/pubmed/37494404 http://dx.doi.org/10.1371/journal.pone.0289051 |
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