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Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis

Circular RNAs (circRNAs) are a new acknowledged class of RNAs that has been shown to play a major role in several biological functions both in physiological and pathological conditions, operating as critical part of regulatory processes, like competing endogenous RNA (ceRNA) networks. The ceRNA hypo...

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Detalles Bibliográficos
Autores principales: Fiscon, Giulia, Funari, Alessio, Paci, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370684/
https://www.ncbi.nlm.nih.gov/pubmed/37494404
http://dx.doi.org/10.1371/journal.pone.0289051
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author Fiscon, Giulia
Funari, Alessio
Paci, Paola
author_facet Fiscon, Giulia
Funari, Alessio
Paci, Paola
author_sort Fiscon, Giulia
collection PubMed
description Circular RNAs (circRNAs) are a new acknowledged class of RNAs that has been shown to play a major role in several biological functions both in physiological and pathological conditions, operating as critical part of regulatory processes, like competing endogenous RNA (ceRNA) networks. The ceRNA hypothesis is a recently discovered molecular mechanism that adds a new key layer of post-transcriptional regulation, whereby various types of RNAs can reciprocally influence each other’s expression competing for binding the same pool of microRNAs, even affecting disease development. In this study, we build a network of circRNA-miRNA-mRNA interactions in human breast cancer, called CERNOMA, that is a bipartite graph with one class of nodes corresponding to differentially expressed miRNAs (DEMs) and the other one corresponding to differentially expressed circRNAs (DEC) and mRNAs (DEGs). A link between a DEC (or DEG) and DEM is placed if it is predicted to be a target of the DEM and shows an opposite expression level trend with respect to the DEM. Within the CERNOMA, we highlighted an interesting deregulated circRNA-miRNA-mRNA triplet, including the up-regulated hsa_circRNA_102908 (BRCA1 associated RING domain 1), the down-regulated miR‐410-3p, and the up-regulated ESM1, whose overexpression has been already shown to promote tumor dissemination and metastasis in breast cancer.
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spelling pubmed-103706842023-07-27 Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis Fiscon, Giulia Funari, Alessio Paci, Paola PLoS One Research Article Circular RNAs (circRNAs) are a new acknowledged class of RNAs that has been shown to play a major role in several biological functions both in physiological and pathological conditions, operating as critical part of regulatory processes, like competing endogenous RNA (ceRNA) networks. The ceRNA hypothesis is a recently discovered molecular mechanism that adds a new key layer of post-transcriptional regulation, whereby various types of RNAs can reciprocally influence each other’s expression competing for binding the same pool of microRNAs, even affecting disease development. In this study, we build a network of circRNA-miRNA-mRNA interactions in human breast cancer, called CERNOMA, that is a bipartite graph with one class of nodes corresponding to differentially expressed miRNAs (DEMs) and the other one corresponding to differentially expressed circRNAs (DEC) and mRNAs (DEGs). A link between a DEC (or DEG) and DEM is placed if it is predicted to be a target of the DEM and shows an opposite expression level trend with respect to the DEM. Within the CERNOMA, we highlighted an interesting deregulated circRNA-miRNA-mRNA triplet, including the up-regulated hsa_circRNA_102908 (BRCA1 associated RING domain 1), the down-regulated miR‐410-3p, and the up-regulated ESM1, whose overexpression has been already shown to promote tumor dissemination and metastasis in breast cancer. Public Library of Science 2023-07-26 /pmc/articles/PMC10370684/ /pubmed/37494404 http://dx.doi.org/10.1371/journal.pone.0289051 Text en © 2023 Fiscon et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fiscon, Giulia
Funari, Alessio
Paci, Paola
Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis
title Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis
title_full Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis
title_fullStr Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis
title_full_unstemmed Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis
title_short Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis
title_sort circular rna mediated gene regulation in human breast cancer: a bioinformatics analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370684/
https://www.ncbi.nlm.nih.gov/pubmed/37494404
http://dx.doi.org/10.1371/journal.pone.0289051
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