Cargando…

High-altitude cerebral hypoxia promotes mitochondrial dysfunction and apoptosis of mouse neurons

INTRODUCTION: Neuronal cell death is an important factor in the pathogenesis of acute high-altitude cerebral hypoxia; however, the underlying molecular mechanism remains unclear. In this study, we tested if high-altitude hypoxia (HAH) causes neuronal death and mitochondrial dysfunction using various...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huan, Yu, Quan, Huilin, Jia, Bo, Hao, Guangzhi, Shi, Zuolin, Zhao, Tianzi, Yuan, Ying, Yuan, Fang, Dong, Yushu, Liang, Guobiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370763/ https://www.ncbi.nlm.nih.gov/pubmed/37501726 http://dx.doi.org/10.3389/fnmol.2023.1216947

Ejemplares similares

Sevoflurane-Induced Apoptosis in the Mouse Cerebral Cortex Follows Similar Characteristics of Physiological Apoptosis
por: Wang, Qi, et al.
Publicado: (2022)

Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema
por: Xue, Yan, et al.
Publicado: (2022)

Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury
por: Yuan, Ying, et al.
Publicado: (2023)

Clinical effectiveness of nimodipine for the prevention of poor outcome after aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis
por: Hao, Guangzhi, et al.
Publicado: (2022)

Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia—an ultrasound and MRI study
por: Wilson, Mark H, et al.
Publicado: (2011)

NADH Fluorescence Lifetime Imaging Microscopy Reveals Selective Mitochondrial Dysfunction in Neurons Overexpressing Alzheimer’s Disease–Related Proteins
por: Niederschweiberer, Moritz A., et al.
Publicado: (2021)

Exendin-4 inhibits high-altitude cerebral edema by protecting against neurobiological dysfunction
por: Sun, Zhong-Lei, et al.
Publicado: (2018)

The BH3 mimetic (±) gossypol induces ROS-independent apoptosis and mitochondrial dysfunction in human A375 melanoma cells in vitro
por: Haasler, Lisa, et al.
Publicado: (2021)

Identification of a hypoxia-regulated miRNA signature in bladder cancer and a role for miR-145 in hypoxia-dependent apoptosis
por: Blick, C, et al.
Publicado: (2015)

Mitochondrial protein dysfunction in pathogenesis of neurological diseases
por: Wang, Liang, et al.
Publicado: (2022)

Lycopene Protects against Hypoxia/Reoxygenation-Induced Apoptosis by Preventing Mitochondrial Dysfunction in Primary Neonatal Mouse Cardiomyocytes
por: Yue, Rongchuan, et al.
Publicado: (2012)

Mitochondrial Dysfunction in Advanced Liver Disease: Emerging Concepts
por: Zhang, Ingrid W., et al.
Publicado: (2021)

The Role of Mitochondrial Dysfunction in Vascular Disease, Tumorigenesis, and Diabetes
por: Zhunina, Olga A., et al.
Publicado: (2021)

Editorial: Mitochondrial dysfunction as a target in neurodegenerative diseases
por: Perrone, Lorena
Publicado: (2023)

Inflammatory gene expression during acute high‐altitude exposure
por: Pham, Kathy, et al.
Publicado: (2022)

Immunometabolic Dysfunction of Natural Killer Cells Mediated by the Hypoxia-CD73 Axis in Solid Tumors
por: Chambers, Andrea M., et al.
Publicado: (2019)

Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications
por: Hu, Xiang-Qun, et al.
Publicado: (2021)

Autophagy Activation by Hypoxia Regulates Angiogenesis and Apoptosis in Oxidized Low-Density Lipoprotein-Induced Preeclampsia
por: Li, Yamei, et al.
Publicado: (2021)

Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium
por: Wang, Yarong, et al.
Publicado: (2021)

Nucleus Tractus Solitarius Neurons Activated by Hypercapnia and Hypoxia Lack Mu Opioid Receptor Expression
por: Maletz, Sebastian N., et al.
Publicado: (2022)

Glutamate Carrier Involvement in Mitochondrial Dysfunctioning in the Brain White Matter
por: Hillen, Anne E. J., et al.
Publicado: (2020)

NEURONAL HYPOXIA DISRUPTS MITOCHONDRIAL FUSION
por: SANDERSON, T. H., et al.
Publicado: (2015)

The Expression Regulatory Network in the Lung Tissue of Tibetan Pigs Provides Insight Into Hypoxia-Sensitive Pathways in High-Altitude Hypoxia
por: Yang, Yanan, et al.
Publicado: (2021)

Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance
por: Browne, G, et al.
Publicado: (2012)

Effects of N-methyl-D-aspartate receptor knockdown and hypoxia/reoxygenation injury on the neuronal proteome and transcriptome
por: He, Jinting, et al.
Publicado: (2022)

Progressive mitochondrial dysfunction in cerebellar synaptosomes of cystatin B-deficient mice
por: Gorski, Katarin, et al.
Publicado: (2023)

Hypoxia-Inducible Factor-1α Protects Cervical Carcinoma Cells from Apoptosis Induced by Radiation via Modulation of Vascular Endothelial Growth Factor and p53 under Hypoxia
por: Fu, Zhichao, et al.
Publicado: (2015)

Induced Neural Stem Cells Protect Neuronal Cells against Apoptosis
por: Kim, Jin Hee, et al.
Publicado: (2014)

NEK7 Coordinates Rapid Neuroinflammation After Subarachnoid Hemorrhage in Mice
por: Li, Gen, et al.
Publicado: (2020)

Fertility in a high-altitude environment is compromised by luteal dysfunction: the relative roles of hypoxia and oxidative stress
por: Parraguez, Víctor H, et al.
Publicado: (2013)

Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia
por: Zhu, Changlian, et al.
Publicado: (2007)

Editorial: Apoptosis, autophagy, and mitophagy dysfunction in Alzheimer's disease: Evolving emergence and mechanisms
por: Kalra, Rajkumar Singh, et al.
Publicado: (2022)

Isolated high altitude psychosis, delirium at high altitude, and high altitude cerebral edema: are these diagnoses valid?
por: Hüfner, Katharina, et al.
Publicado: (2023)

Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer’s disease?
por: Sbai, Oualid, et al.
Publicado: (2023)

CD38-Induced Apoptosis and Mitochondrial Damage is Restored by Nicotinamide in Prostate Cancer
por: Kanayama, Mayuko, et al.
Publicado: (2022)

Lin28a Protects against Hypoxia/Reoxygenation Induced Cardiomyocytes Apoptosis by Alleviating Mitochondrial Dysfunction under High Glucose/High Fat Conditions
por: Zhang, Mingming, et al.
Publicado: (2014)

The Magnitude of Diving Bradycardia During Apnea at Low-Altitude Reveals Tolerance to High Altitude Hypoxia
por: Holmström, Pontus, et al.
Publicado: (2019)

Hypoxia-altitude simulation test to predict altitude-related adverse health effects in COPD patients
por: Bauer, Meret, et al.
Publicado: (2023)

Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
por: Xin, Jingxue, et al.
Publicado: (2020)

Analysis of Altitude Hypoxia Training and In-Flight Hypoxia Events among the Helicopter Aircrews
por: Chiang, Kwo-Tsao, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7rrjck28ngtqvaesk30ha59v9a