Clinical Characteristics of Corynebacterium ulcerans Infection, Japan

Corynebacterium ulcerans is a closely related bacterium to the diphtheria bacterium C. diphtheriae, and some C. ulcerans strains produce toxins that are similar to diphtheria toxin. C. ulcerans is widely distributed in the environment and is considered one of the most harmful pathogens to livestock...

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Detalles Bibliográficos
Autores principales: Yamamoto, Akihiko, Hifumi, Toru, Ato, Manabu, Iwaki, Masaaki, Senoh, Mitsutoshi, Hatanaka, Akio, Nureki, Shinichi, Noguchi, Yoshihiro, Hirose, Tomoko, Yoshimura, Yukihiro, Urakawa, Takaaki, Hori, Shiro, Nakada, Hiroto, Terada, Tomomasa, Ishifuji, Tomoko, Matsuyama, Hisayo, Kinebuchi, Takahiro, Fukushima, Atsuhito, Wake, Koji, Otsuji, Ken, Endo, Takeru, Toyoshima, Hirokazu, Yasuda, Ikkoh, Tanaka, Takeshi, Takahashi, Naoki, Okada, Kensaku, Hayashi, Toshimasa, Kusano, Taizo, Koriyama, Minami, Otani, Norio, Takahashi, Motohide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Synopsis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370844/
https://www.ncbi.nlm.nih.gov/pubmed/37486266
http://dx.doi.org/10.3201/eid2908.220058
Descripción
Sumario:Corynebacterium ulcerans is a closely related bacterium to the diphtheria bacterium C. diphtheriae, and some C. ulcerans strains produce toxins that are similar to diphtheria toxin. C. ulcerans is widely distributed in the environment and is considered one of the most harmful pathogens to livestock and wildlife. Infection with C. ulcerans can cause respiratory or nonrespiratory symptoms in patients. Recently, the microorganism has been increasingly recognized as an emerging zoonotic agent of diphtheria-like illness in Japan. To clarify the overall clinical characteristics, treatment-related factors, and outcomes of C. ulcerans infection, we analyzed 34 cases of C. ulcerans that occurred in Japan during 2001–2020. During 2010–2020, the incidence rate of C. ulcerans infection increased markedly, and the overall mortality rate was 5.9%. It is recommended that adults be vaccinated with diphtheria toxoid vaccine to prevent the spread of this infection.

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