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Healthcare-Associated Infections Caused by Mycolicibacterium neoaurum

Mycolicibacterium neoaurum is a rapidly growing mycobacterium and an emerging cause of human infections. M. neoaurum infections are uncommon but likely underreported, and our understanding of the disease spectrum and optimum management is incomplete. We summarize demographic and clinical characteris...

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Autores principales: Shapiro, Kate, Cross, Shane J., Morton, Ted H., Inaba, Hiroto, Holland, Ashley, Fasipe, Francisca R., Adderson, Elisabeth E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370869/
https://www.ncbi.nlm.nih.gov/pubmed/37486155
http://dx.doi.org/10.3201/eid2908.230007
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author Shapiro, Kate
Cross, Shane J.
Morton, Ted H.
Inaba, Hiroto
Holland, Ashley
Fasipe, Francisca R.
Adderson, Elisabeth E.
author_facet Shapiro, Kate
Cross, Shane J.
Morton, Ted H.
Inaba, Hiroto
Holland, Ashley
Fasipe, Francisca R.
Adderson, Elisabeth E.
author_sort Shapiro, Kate
collection PubMed
description Mycolicibacterium neoaurum is a rapidly growing mycobacterium and an emerging cause of human infections. M. neoaurum infections are uncommon but likely underreported, and our understanding of the disease spectrum and optimum management is incomplete. We summarize demographic and clinical characteristics of a case of catheter-related M. neoaurum bacteremia in a child with leukemia and those of 36 previously reported episodes of M. neoaurum infection. Most infections occurred in young to middle-aged adults with serious underlying medical conditions and commonly involved medical devices. Overall, infections were not associated with severe illness or death. In contrast to other mycobacteria species, M. neoaurum was generally susceptible to multiple antimicrobial drugs and responded promptly to treatment, and infections were associated with good outcomes after relatively short therapy duration and device removal. Delays in identification and susceptibility testing were common. We recommend using combination antimicrobial drug therapy and removal of infected devices to eradicate infection.
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spelling pubmed-103708692023-08-01 Healthcare-Associated Infections Caused by Mycolicibacterium neoaurum Shapiro, Kate Cross, Shane J. Morton, Ted H. Inaba, Hiroto Holland, Ashley Fasipe, Francisca R. Adderson, Elisabeth E. Emerg Infect Dis Synopsis Mycolicibacterium neoaurum is a rapidly growing mycobacterium and an emerging cause of human infections. M. neoaurum infections are uncommon but likely underreported, and our understanding of the disease spectrum and optimum management is incomplete. We summarize demographic and clinical characteristics of a case of catheter-related M. neoaurum bacteremia in a child with leukemia and those of 36 previously reported episodes of M. neoaurum infection. Most infections occurred in young to middle-aged adults with serious underlying medical conditions and commonly involved medical devices. Overall, infections were not associated with severe illness or death. In contrast to other mycobacteria species, M. neoaurum was generally susceptible to multiple antimicrobial drugs and responded promptly to treatment, and infections were associated with good outcomes after relatively short therapy duration and device removal. Delays in identification and susceptibility testing were common. We recommend using combination antimicrobial drug therapy and removal of infected devices to eradicate infection. Centers for Disease Control and Prevention 2023-08 /pmc/articles/PMC10370869/ /pubmed/37486155 http://dx.doi.org/10.3201/eid2908.230007 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Synopsis
Shapiro, Kate
Cross, Shane J.
Morton, Ted H.
Inaba, Hiroto
Holland, Ashley
Fasipe, Francisca R.
Adderson, Elisabeth E.
Healthcare-Associated Infections Caused by Mycolicibacterium neoaurum
title Healthcare-Associated Infections Caused by Mycolicibacterium neoaurum
title_full Healthcare-Associated Infections Caused by Mycolicibacterium neoaurum
title_fullStr Healthcare-Associated Infections Caused by Mycolicibacterium neoaurum
title_full_unstemmed Healthcare-Associated Infections Caused by Mycolicibacterium neoaurum
title_short Healthcare-Associated Infections Caused by Mycolicibacterium neoaurum
title_sort healthcare-associated infections caused by mycolicibacterium neoaurum
topic Synopsis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370869/
https://www.ncbi.nlm.nih.gov/pubmed/37486155
http://dx.doi.org/10.3201/eid2908.230007
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