Loss of metabolic fitness drives tumor resistance after CAR-NK cell therapy and can be overcome by cytokine engineering

Chimeric antigen receptor (CAR) engineering of natural killer (NK) cells is promising, with early-phase clinical studies showing encouraging responses. However, the transcriptional signatures that control the fate of CAR-NK cells after infusion and factors that influence tumor control remain poorly...

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Detalles Bibliográficos
Autores principales: Li, Li, Mohanty, Vakul, Dou, Jinzhuang, Huang, Yuefan, Banerjee, Pinaki P., Miao, Qi, Lohr, Jens G., Vijaykumar, Tushara, Frede, Julia, Knoechel, Birgit, Muniz-Feliciano, Luis, Laskowski, Tamara J., Liang, Shaoheng, Moyes, Judy S., Nandivada, Vandana, Basar, Rafet, Kaplan, Mecit, Daher, May, Liu, Enli, Li, Ye, Acharya, Sunil, Lin, Paul, Shanley, Mayra, Rafei, Hind, Marin, David, Mielke, Stephan, Champlin, Richard E., Shpall, Elizabeth J., Chen, Ken, Rezvani, Katayoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371011/
https://www.ncbi.nlm.nih.gov/pubmed/37494448
http://dx.doi.org/10.1126/sciadv.add6997

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