Multi-tiered approach to detect autoimmune cross-reactivity of therapeutic T cell receptors

T cell receptor (TCR)–engineered T cell therapy using high-affinity TCRs is a promising treatment modality for cancer. Discovery of high-affinity TCRs especially against self-antigens can require approaches that circumvent central tolerance, which may increase the risk of cross-reactivity. Despite t...

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Detalles Bibliográficos
Autores principales: Ishii, Kazusa, Davies, John S., Sinkoe, Andrew L., Nguyen, Kilyna A., Norberg, Scott M., McIntosh, Crystal P., Kadakia, Tejas, Serna, Carylinda, Rae, Zachary, Kelly, Michael C., Hinrichs, Christian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371023/
https://www.ncbi.nlm.nih.gov/pubmed/37494434
http://dx.doi.org/10.1126/sciadv.adg9845

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