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Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair

Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell death can interfere with such programs and cause organ failure. Cellular FLICE-like inhibitory protein (cFLIP) is a crucial regulator of cell death and a substrate of Caspase-8. However, the ph...

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Detalles Bibliográficos
Autores principales: Martinez Lagunas, Kristel, Savcigil, Deniz Pinar, Zrilic, Matea, Carvajal Fraile, Carlos, Craxton, Andrew, Self, Emily, Uranga-Murillo, Iratxe, de Miguel, Diego, Arias, Maykel, Willenborg, Sebastian, Piekarek, Michael, Albert, Marie Christine, Nugraha, Kalvin, Lisewski, Ina, Janakova, Erika, Igual, Natalia, Tonnus, Wulf, Hildebrandt, Ximena, Ibrahim, Mohammed, Ballegeer, Marlies, Saelens, Xavier, Kueh, Andrew, Meier, Pascal, Linkermann, Andreas, Pardo, Julian, Eming, Sabine, Walczak, Henning, MacFarlane, Marion, Peltzer, Nieves, Annibaldi, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371024/
https://www.ncbi.nlm.nih.gov/pubmed/37494451
http://dx.doi.org/10.1126/sciadv.adg2829