Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr(682)-phosphorylated APP βCTF

Lysosome dysfunction arises early and propels Alzheimer’s disease (AD). Herein, we show that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts directly via its β-C-terminal fragment (βCTF) to disrupt lysosomal vacuolar (H(+))–adenosine triphosphatase (v-ATPase) an...

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Detalles Bibliográficos
Autores principales: Im, Eunju, Jiang, Ying, Stavrides, Philip H., Darji, Sandipkumar, Erdjument-Bromage, Hediye, Neubert, Thomas A., Choi, Jun Yong, Wegiel, Jerzy, Lee, Ju-Hyun, Nixon, Ralph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371027/
https://www.ncbi.nlm.nih.gov/pubmed/37494443
http://dx.doi.org/10.1126/sciadv.adg1925

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