FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration

This study establishes the physiological role of Fused in Sarcoma (FUS) in mitochondrial DNA (mtDNA) repair and highlights its implications to the pathogenesis of FUS-associated neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS). Endogenous FUS interacts with and recruits mtDNA L...

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Detalles Bibliográficos
Autores principales: Kodavati, Manohar, Wang, Haibo, Guo, Wenting, Mitra, Joy, Hegde, Pavana M., Provasek, Vincent, Maloji Rao, Vikas H, Vedula, Indira, Zhang, Aijun, Mitra, Sankar, Tomkinson, Alan E., Hamilton, Dale J., Bosch, Ludo Van Den, Hegde, Muralidhar L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371073/
https://www.ncbi.nlm.nih.gov/pubmed/37502965
http://dx.doi.org/10.21203/rs.3.rs-3152718/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371073/
https://www.ncbi.nlm.nih.gov/pubmed/37502965
http://dx.doi.org/10.21203/rs.3.rs-3152718/v1

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