Allosteric control of dynamin-related protein 1-catalyzed mitochondrial fission through a conserved disordered C-terminal Short Linear Motif

The mechanochemical GTPase dynamin-related protein 1 (Drp1) catalyzes mitochondrial fission, but the regulatory mechanisms remain ambiguous. Here we found that a conserved, intrinsically disordered, six-residue Short Linear Motif at the extreme Drp1 C-terminus, named CT-SLiM, constitutes a critical...

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Detalles Bibliográficos
Autores principales: Pérez-Jover, Isabel, Rochon, Kristy, Hu, Di, Mohan, Pooja Madan, Santos-Perez, Isaac, Gisasola, Julene Ormaetxea, Galvez, Juan Manuel Martinez, Agirre, Jon, Qi, Xin, Mears, Jason A., Shnyrova, Anna V., Ramachandran, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371074/
https://www.ncbi.nlm.nih.gov/pubmed/37503116
http://dx.doi.org/10.21203/rs.3.rs-3161608/v2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371074/
https://www.ncbi.nlm.nih.gov/pubmed/37503116
http://dx.doi.org/10.21203/rs.3.rs-3161608/v2

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