UV-B induced HSV-1 reactivation leads to infectious virus in the corneas of virtually all latently infected mice and requires an intact STING to develop herpetic stromal keratitis

Reactivation of latent herpes simplex type 1 results in virus returning to the cornea leading to recurrent herpetic stromal keratitis (rHSK). We compare two competing models to reactivate viruses from latency, UV-B irradiation and cyclophosphamide. Results revealed that while both result in corneal...

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Detalles Bibliográficos
Autores principales: Yin, Xiao-Tang, Hartman, Alexis, Sirajuddin, Nadia, Shukla, Deepak, St. Leger, Anthony, Keadle, Tammie L., Stuart, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371093/
https://www.ncbi.nlm.nih.gov/pubmed/37502845
http://dx.doi.org/10.21203/rs.3.rs-3097720/v1

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