A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis

Obesity-related type II diabetes (diabesity) has increased global morbidity and mortality dramatically. Previously, the ancient drug salicylate demonstrated promise for the treatment of type II diabetes, but its clinical use was precluded due to high dose requirements. In this study, we present a ni...

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Detalles Bibliográficos
Autores principales: Cal, Karina, Leyva, Alejandro, Rodríguez-Duarte, Jorge, Ruiz, Santiago, Santos, Leonardo, Colella, Lucía, Ingold, Mariana, Vilaseca, Cecilia, Galliussi, German, Ziegler, Lucía, Peclat, Thais R., Bresque, Mariana, Handy, Rachel M, King, Rachel, dos Reis, Larissa Menezes, Espasandin, Camila, Breining, Peter, Dapueto, Rosina, Lopez, Andrés, Thompson, Katie L., Agorrody, Guillermo, DeVallance, Evan, Meadows, Ethan, Lewis, Sara E., Barbosa, Gabriele Catarine Santana, de Souza, Leonardo Osbourne Lai, Chichierchio, Marina Santos, Valez, Valeria, Aicardo, Adrián, Contreras, Paola, Vendelbo, Mikkel H., Jakobsen, Steen, Kamaid, Andrés, Porcal, Williams, Calliari, Aldo, Verdes, José Manuel, Du, Jianhai, Wang, Yekai, Hollander, John M, White, Thomas A., Radi, Rafael, Moyna, Guillermo, Quijano, Celia, O’Doherty, Robert, Moraes-Vieira, Pedro, Holloway, Graham P, Leonardi, Roberta, Mori, Marcelo A, Camacho-Pereira, Juliana, Kelley, Eric E., Duran, Rosario, Lopez, Gloria V., Batthyány, Carlos, Chini, Eduardo N., Escande, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371099/
https://www.ncbi.nlm.nih.gov/pubmed/37502859
http://dx.doi.org/10.21203/rs.3.rs-3101395/v1

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