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Welding fume exposure is associated with medial temporal lobe microstructural features resembling early Alzheimer disease

INTRODUCTION: Welding fumes contain a mixture of metals and are an epitype for environmental metal-related neurotoxicity. Past studies of welders focused largely on basal ganglia regions and their association with parkinsonism. This study evaluated medial temporal lobe (MTL) structures that play a k...

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Autores principales: Lee, Eun-Young, Kim, Juhee, Prado-Rico, Janina Manzieri, Du, Guangwei, Lewis, Mechelle M., Kong, Lan, Yanosky, Jeff D., Eslinger, Paul J., Kim, Byoung-Gwon, Hong, Young-Seoub, Mailman, Richard B., Huang, Xuemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371112/
https://www.ncbi.nlm.nih.gov/pubmed/37503124
http://dx.doi.org/10.1101/2023.07.18.23292828
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author Lee, Eun-Young
Kim, Juhee
Prado-Rico, Janina Manzieri
Du, Guangwei
Lewis, Mechelle M.
Kong, Lan
Yanosky, Jeff D.
Eslinger, Paul J.
Kim, Byoung-Gwon
Hong, Young-Seoub
Mailman, Richard B.
Huang, Xuemei
author_facet Lee, Eun-Young
Kim, Juhee
Prado-Rico, Janina Manzieri
Du, Guangwei
Lewis, Mechelle M.
Kong, Lan
Yanosky, Jeff D.
Eslinger, Paul J.
Kim, Byoung-Gwon
Hong, Young-Seoub
Mailman, Richard B.
Huang, Xuemei
author_sort Lee, Eun-Young
collection PubMed
description INTRODUCTION: Welding fumes contain a mixture of metals and are an epitype for environmental metal-related neurotoxicity. Past studies of welders focused largely on basal ganglia regions and their association with parkinsonism. This study evaluated medial temporal lobe (MTL) structures that play a key role in Alzheimer’s disease-like pathology. METHODS: Exposure history and whole blood metal levels were obtained from subjects with/without a history of welding (42 welders; 31 controls). MTL regions of interest (ROI) (hippocampus, entorhinal and parahippocampal cortices) were assessed by morphologic (volume and cortical thickness) and diffusion tensor imaging [mean (MD), axial (AD), radial diffusivity (RD) and fractional anisotropy (FA)] metrics. Cognition was evaluated using standard neuropsychological tests. RESULTS: Welders had higher blood levels of Cu, Fe, K, Mn, Pb, Se, and Zn (p’s<0.026) than controls. Welders had higher MD, AD, and RD in all MTL ROIs (p’s<0.040) and lower FA in the entorhinal and parahippocampal cortices (p’s<0.033) without significant morphologic differences. Welders also exhibited lower performance on processing/psychomotor speed, executive, and visuospatial function domains (p’s<0.046). Greater welding years predicted lower parahippocampal FA (p=0.011), where greater short-term welding intensity (E90) predicted worse Symbol coding digit scores (p=0.019). Blood Mn and Cu levels demonstrated robust relationships with entorhinal diffusivity (p’s<0.009) and story recall performance (p=0.003), respectively, throughout correlation, semi-parametric regression, and Bayesian kernel machine regression analyses. DISCUSSION: Welding fumes and related metal exposures are associated with MTL features of early Alzheimer’s disease. Given the ubiquitous nature of metal exposure, future studies are warranted and may have public health implications.
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spelling pubmed-103711122023-07-27 Welding fume exposure is associated with medial temporal lobe microstructural features resembling early Alzheimer disease Lee, Eun-Young Kim, Juhee Prado-Rico, Janina Manzieri Du, Guangwei Lewis, Mechelle M. Kong, Lan Yanosky, Jeff D. Eslinger, Paul J. Kim, Byoung-Gwon Hong, Young-Seoub Mailman, Richard B. Huang, Xuemei medRxiv Article INTRODUCTION: Welding fumes contain a mixture of metals and are an epitype for environmental metal-related neurotoxicity. Past studies of welders focused largely on basal ganglia regions and their association with parkinsonism. This study evaluated medial temporal lobe (MTL) structures that play a key role in Alzheimer’s disease-like pathology. METHODS: Exposure history and whole blood metal levels were obtained from subjects with/without a history of welding (42 welders; 31 controls). MTL regions of interest (ROI) (hippocampus, entorhinal and parahippocampal cortices) were assessed by morphologic (volume and cortical thickness) and diffusion tensor imaging [mean (MD), axial (AD), radial diffusivity (RD) and fractional anisotropy (FA)] metrics. Cognition was evaluated using standard neuropsychological tests. RESULTS: Welders had higher blood levels of Cu, Fe, K, Mn, Pb, Se, and Zn (p’s<0.026) than controls. Welders had higher MD, AD, and RD in all MTL ROIs (p’s<0.040) and lower FA in the entorhinal and parahippocampal cortices (p’s<0.033) without significant morphologic differences. Welders also exhibited lower performance on processing/psychomotor speed, executive, and visuospatial function domains (p’s<0.046). Greater welding years predicted lower parahippocampal FA (p=0.011), where greater short-term welding intensity (E90) predicted worse Symbol coding digit scores (p=0.019). Blood Mn and Cu levels demonstrated robust relationships with entorhinal diffusivity (p’s<0.009) and story recall performance (p=0.003), respectively, throughout correlation, semi-parametric regression, and Bayesian kernel machine regression analyses. DISCUSSION: Welding fumes and related metal exposures are associated with MTL features of early Alzheimer’s disease. Given the ubiquitous nature of metal exposure, future studies are warranted and may have public health implications. Cold Spring Harbor Laboratory 2023-07-23 /pmc/articles/PMC10371112/ /pubmed/37503124 http://dx.doi.org/10.1101/2023.07.18.23292828 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Lee, Eun-Young
Kim, Juhee
Prado-Rico, Janina Manzieri
Du, Guangwei
Lewis, Mechelle M.
Kong, Lan
Yanosky, Jeff D.
Eslinger, Paul J.
Kim, Byoung-Gwon
Hong, Young-Seoub
Mailman, Richard B.
Huang, Xuemei
Welding fume exposure is associated with medial temporal lobe microstructural features resembling early Alzheimer disease
title Welding fume exposure is associated with medial temporal lobe microstructural features resembling early Alzheimer disease
title_full Welding fume exposure is associated with medial temporal lobe microstructural features resembling early Alzheimer disease
title_fullStr Welding fume exposure is associated with medial temporal lobe microstructural features resembling early Alzheimer disease
title_full_unstemmed Welding fume exposure is associated with medial temporal lobe microstructural features resembling early Alzheimer disease
title_short Welding fume exposure is associated with medial temporal lobe microstructural features resembling early Alzheimer disease
title_sort welding fume exposure is associated with medial temporal lobe microstructural features resembling early alzheimer disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371112/
https://www.ncbi.nlm.nih.gov/pubmed/37503124
http://dx.doi.org/10.1101/2023.07.18.23292828
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