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Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Pubertal timing varies considerably and has been associated with a range of health outcomes in later life. To elucidate the underlying biological mechanisms, we performed multi-ancestry genetic analyses in ~800,000 women, identifying 1,080 independent signals associated with age at menarche. Collect...

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Detalles Bibliográficos
Autores principales: Kentistou, Katherine A, Kaisinger, Lena R, Stankovic, Stasa, Vaudel, Marc, de Oliveira, Edson M, Messina, Andrea, Walters, Robin G, Liu, Xiaoxi, Busch, Alexander S, Helgason, Hannes, Thompson, Deborah J, Santon, Federico, Petricek, Konstantin M, Zouaghi, Yassine, Huang-Doran, Isabel, Gudbjartsson, Daniel F, Bratland, Eirik, Lin, Kuang, Gardner, Eugene J, Zhao, Yajie, Jia, Raina, Terao, Chikashi, Riggan, Margie, Bolla, Manjeet K, Yazdanpanah, Mojgan, Yazdanpanah, Nahid, Bradfield, Jonath P, Broer, Linda, Campbell, Archie, Chasman, Daniel I, Cousminer, Diana L, Franceschini, Nora, Franke, Lude H, Girotto, Giorgia, He, Chunyan, Järvelin, Marjo-Riitta, Joshi, Peter K, Kamatani, Yoichiro, Karlsson, Robert, Luan, Jian’an, Lunetta, Kathryn L, Mägi, Reedik, Mangino, Massimo, Medland, Sarah E, Meisinger, Christa, Noordam, Raymond, Nutile, Teresa, Concas, Maria Pina, Polašek, Ozren, Porcu, Eleonora, Ring, Susan M, Sala, Cinzia, Smith, Albert V, Tanaka, Toshiko, van der Most, Peter J, Vitart, Veronique, Wang, Carol A, Willemsen, Gonneke, Zygmunt, Marek, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Auer, Paul L, Barnes, Catriona LK, Beckmann, Matthias W, Berrington, Amy, Bogdanova, Natalia V, Bojesen, Stig E, Brenner, Hermann, Buring, Julie E, Canzian, Federico, Chang-Claude, Jenny, Couch, Fergus J, Cox, Angela, Crisponi, Laura, Czene, Kamila, Daly, Mary B, Demerath, Ellen W, Dennis, Joe, Devilee, Peter, Vivo, Immaculata De, Dörk, Thilo, Dunning, Alison M, Dwek, Miriam, Eriksson, Johan G, Fasching, Peter A, Fernandez-Rhodes, Lindsay, Ferreli, Liana, Fletcher, Olivia, Gago-Dominguez, Manuela, García-Closas, Montserrat, García-Sáenz, José A, González-Neira, Anna, Grallert, Harald, Guénel, Pascal, Haiman, Christopher A, Hall, Per, Hamann, Ute, Hakonarson, Hakon, Hart, Roger J, Hickey, Martha, Hooning, Maartje J, Hoppe, Reiner, Hopper, John L, Hottenga, Jouke-Jan, Hu, Frank B, Hübner, Hanna, Hunter, David J, Jernström, Helena, John, Esther M, Karasik, David, Khusnutdinova, Elza K, Kristensen, Vessela N, Lacey, James V, Lambrechts, Diether, Launer, Lenore J, Lind, Penelope A, Lindblom, Annika, Magnusson, Patrik KE, Mannermaa, Arto, McCarthy, Mark I, Meitinger, Thomas, Menni, Cristina, Michailidou, Kyriaki, Millwood, Iona Y, Milne, Roger L, Montgomery, Grant W, Nevanlinna, Heli, Nolte, Ilja M, Nyholt, Dale R, Obi, Nadia, O’Brien, Katie M, Offit, Kenneth, Oldehinkel, Albertine J, Ostrowski, Sisse R, Palotie, Aarno, Pedersen, Ole B, Peters, Annette, Pianigiani, Giulia, Plaseska-Karanfilska, Dijana, Pouta, Anneli, Pozarickij, Alfred, Radice, Paolo, Rennert, Gad, Rosendaal, Frits R, Ruggiero, Daniela, Saloustros, Emmanouil, Sandler, Dale P, Schipf, Sabine, Schmidt, Carsten O, Schmidt, Marjanka K, Small, Kerrin, Spedicati, Beatrice, Stampfer, Meir, Stone, Jennifer, Tamimi, Rulla M, Teras, Lauren R, Tikkanen, Emmi, Turman, Constance, Vachon, Celine M, Wang, Qin, Winqvist, Robert, Wolk, Alicja, Zemel, Babette S, Zheng, Wei, van Dijk, Ko W, Alizadeh, Behrooz Z, Bandinelli, Stefania, Boerwinkle, Eric, Boomsma, Dorret I, Ciullo, Marina, Chenevix-Trench, Georgia, Cucca, Francesco, Esko, Tõnu, Gieger, Christian, Grant, Struan FA, Gudnason, Vilmundur, Hayward, Caroline, Kolčić, Ivana, Kraft, Peter, Lawlor, Deborah A, Martin, Nicholas G, Nøhr, Ellen A, Pedersen, Nancy L, Pennell, Craig E, Ridker, Paul M, Robino, Antonietta, Snieder, Harold, Sovio, Ulla, Spector, Tim D, Stöckl, Doris, Sudlow, Cathie, Timpson, Nic J, Toniolo, Daniela, Uitterlinden, André, Ulivi, Sheila, Völzke, Henry, Wareham, Nicholas J, Widen, Elisabeth, Wilson, James F, Pharoah, Paul DP, Li, Liming, Easton, Douglas F, Njølstad, Pål, Sulem, Patrick, Murabito, Joanne M, Murray, Anna, Manousaki, Despoina, Juul, Anders, Erikstrup, Christian, Stefansson, Kari, Horikoshi, Momoko, Chen, Zhengming, Farooqi, I Sadaf, Pitteloud, Nelly, Johansson, Stefan, Day, Felix R, Perry, John RB, Ong, Ken K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371120/
https://www.ncbi.nlm.nih.gov/pubmed/37503126
http://dx.doi.org/10.1101/2023.06.14.23291322