Germline Genetic NBN Variation and Predisposition to B-cell Acute Lymphoblastic Leukemia in Children

Biallelic mutation in the DNA-damage repair gene NBN is the genetic cause of Nijmegen Breakage Syndrome, which is associated with predisposition to lymphoid malignancies. Heterozygous carriers of germline NBN variants may also be at risk for leukemia development, although this is much less character...

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Detalles Bibliográficos
Autores principales: Escherich, Carolin, Chen, Wenan, Li, Yizhen, Yang, Wenjian, Nishii, Rina, Li, Zhenhua, Raetz, Elizabeth A., Devidas, Meenakshi, Wu, Gang, Nichols, Kim E., Inaba, Hiroto, Pui, Ching-Hon, Jeha, Sima, Camitta, Bruce M., Larsen, Eric, Hunger, Stephen P., Loh, Mignon L., Yang, Jun J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371123/
https://www.ncbi.nlm.nih.gov/pubmed/37503171
http://dx.doi.org/10.21203/rs.3.rs-3171814/v1

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