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Vactosertib, a novel TGF-β1 type I receptor kinase inhibitor, improves T-cell fitness: a single-arm, phase 1b trial in relapsed/refractory multiple myeloma

Functional blockade of the transforming growth factor-beta (TGF-β) signaling pathway improves the efficacy of cytotoxic and immunotherapies. We conducted a phase 1b study to determine the safety, efficacy, and maximal tolerated dose (200 mg po bid) of the potent, orally-available TGF-β type I recept...

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Detalles Bibliográficos
Autores principales:	Malek, Ehsan, Rana, Priyanka S., Swamydas, Muthulekha, Daunov, Michael, Miyagi, Masaru, Murphy, Elena, Ignatz-Hoover, James J., Metheny, Leland, Seong Jin, Kim, Driscoll, James J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371138/ https://www.ncbi.nlm.nih.gov/pubmed/37503043 http://dx.doi.org/10.21203/rs.3.rs-3112163/v1

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