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Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases

Extracellular matrix proteins harbor signaling domains that once released from the parent molecule can trigger cellular responses. One of these molecules is endotrophin, a type VI collagen derived fragment, whose circulatory levels have been associated to an increased risk of adverse outcome in hear...

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Autores principales: Reese-Petersen, Alexander L., Genovese, Federica, Zhao, Lei, Banks, Glen, Gordon, David A., Karsdal, Morten A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371192/
https://www.ncbi.nlm.nih.gov/pubmed/37503538
http://dx.doi.org/10.3389/fmolb.2023.1228232
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author Reese-Petersen, Alexander L.
Genovese, Federica
Zhao, Lei
Banks, Glen
Gordon, David A.
Karsdal, Morten A.
author_facet Reese-Petersen, Alexander L.
Genovese, Federica
Zhao, Lei
Banks, Glen
Gordon, David A.
Karsdal, Morten A.
author_sort Reese-Petersen, Alexander L.
collection PubMed
description Extracellular matrix proteins harbor signaling domains that once released from the parent molecule can trigger cellular responses. One of these molecules is endotrophin, a type VI collagen derived fragment, whose circulatory levels have been associated to an increased risk of adverse outcome in heart failure with preserved ejection fraction (HFpEF). Here we show that the stimulation of human cardiac fibroblasts by endotrophin upregulates the synthesis of type I collagen, the main interstitial collagen that accumulates in the myocardium during fibrogenesis. These data provide a possible mechanistic explanation for the relation between circulating endotrophin levels and risk of outcome in HFpEF.
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spelling pubmed-103711922023-07-27 Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases Reese-Petersen, Alexander L. Genovese, Federica Zhao, Lei Banks, Glen Gordon, David A. Karsdal, Morten A. Front Mol Biosci Molecular Biosciences Extracellular matrix proteins harbor signaling domains that once released from the parent molecule can trigger cellular responses. One of these molecules is endotrophin, a type VI collagen derived fragment, whose circulatory levels have been associated to an increased risk of adverse outcome in heart failure with preserved ejection fraction (HFpEF). Here we show that the stimulation of human cardiac fibroblasts by endotrophin upregulates the synthesis of type I collagen, the main interstitial collagen that accumulates in the myocardium during fibrogenesis. These data provide a possible mechanistic explanation for the relation between circulating endotrophin levels and risk of outcome in HFpEF. Frontiers Media S.A. 2023-07-12 /pmc/articles/PMC10371192/ /pubmed/37503538 http://dx.doi.org/10.3389/fmolb.2023.1228232 Text en Copyright © 2023 Reese-Petersen, Genovese, Zhao, Banks, Gordon and Karsdal. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Reese-Petersen, Alexander L.
Genovese, Federica
Zhao, Lei
Banks, Glen
Gordon, David A.
Karsdal, Morten A.
Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases
title Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases
title_full Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases
title_fullStr Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases
title_full_unstemmed Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases
title_short Endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases
title_sort endotrophin, a fibroblast matrikine, may be a driver of fibroblast activation in fibro-inflammatory diseases
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371192/
https://www.ncbi.nlm.nih.gov/pubmed/37503538
http://dx.doi.org/10.3389/fmolb.2023.1228232
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